Table 2 Adjusted associations of Self-Rated Health Status with Epigenetic Aging Biomarkers (n = 2343)â€
| Â | Main model | Â | Leukocyte-adjusted model | Â |
|---|---|---|---|---|
Biomarker | Estimate (95% CI) | P-value | Estimate (95% CI) | P-value |
 HannumAge (years) | − 0.58 (− 1.65, 0.48) | 0.23 | − 0.30 (− 1.35, 0.76) | 0.52 |
 HorvathAge (years) | − 0.20 (− 1.08, 0.68) | 0.60 | − 0.07 (− 0.91, 0.77) | 0.85 |
 SkinBloodAge (years) | − 0.26 (− 1.01, 0.50) | 0.44 | − 0.13 (− 0.93, 0.67) | 0.71 |
 PhenoAge (years) | − 1.58 (− 2.54, − 0.62) | 0.006 | − 1.15 (− 1.95, − 0.34) | 0.01 |
 GrimAge2 (years) | − 1.16 (− 1.80, − 0.53) | 0.004 | − 0.82 (− 1.38, − 0.26) | 0.01 |
 DNAmTL (kb) | 0.01 (− 0.03, 0.05) | 0.52 | 0.01 (− 0.02, 0.05) | 0.41 |
 DunedinPoAm | − 0.02 (− 0.03, − 0.003) | 0.02 | − 0.01 (− 0.02, 0.0004) | 0.06 |
GrimAge2 components | ||||
 A1c | − 0.005 (− 0.01, 0.0005) | 0.07 | − 0.005 (− 0.01, 0.0005) | 0.07 |
 ADM | − 2.56 (− 5.59, 0.46) | 0.08 | − 1.97 (− 4.82, 0.87) | 0.14 |
 B2M | − 14,933.17 (− 28777.27, − 1089.07) | 0.04 | − 10261.59 (− 24409.55, 3886.36) | 0.13 |
 CRP | − 0.10 (− 0.18, − 0.01) | 0.03 | − 0.08 (− 0.15, − 0.01) | 0.04 |
 Cystatin C | − 3677.57 (− 7726.6, 371.46) | 0.07 | − 2388.38 (− 5303.76, 527.01) | 0.09 |
 GDF15 | − 9.14 (− 25.59, 7.32) | 0.23 | − 6.41 (− 24.24, 11.43) | 0.42 |
 Leptin | − 221.52 (− 493.07, 50.03) | 0.09 | − 359.08 (− 692.38, − 25.78) | 0.04 |
 Packyears | − 1.54 (− 3.04, − 0.04) | 0.045 | − 1.26 (− 2.75, 0.23) | 0.08 |
 PAI1 | − 320.81 (− 778.98, 137.36) | 0.14 | − 279.61 (− 703.69, 144.48) | 0.16 |
 TIMP1 | − 90.77 (− 189.84, 8.3) | 0.07 | − 37.81 (− 122.8, 47.19) | 0.32 |