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Table 3 Associations between AgeAccelGrim2 tertiles and mortality outcomes among participants with diabetes and pre-diabetes

From: Unveiling the impact of DNA-methylation age acceleration on mortality risk in diabetes and pre-diabetes: insights from the US NHANES program

 

Overall participants

Participants with diabetes

Participants with pre-diabetes

 

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Overall survival

662 deaths

 

347 deaths

 

315 deaths

 

AgeAccelGrim2 T1

Reference

Reference

Reference

Reference

Reference

Reference

AgeAccelGrim2 T2

1.113 (0.906, 1.367)

0.310

1.022 (0.775, 1.349)

0.875

1.171 (0.863, 1.590)

0.310

AgeAccelGrim2 T3

1.619 (1.298, 2.019)

 < 0.001

1.515 (1.128, 2.036)

0.006

1.568 (1.119, 2.199)

0.009

Cardiovascular Death

187 deaths

 

103 deaths

 

84 deaths

 

AgeAccelGrim2 T1

Reference

Reference

Reference

Reference

Reference

Reference

AgeAccelGrim2 T2

1.039 (0.700, 1.542)

0.849

1.001 (0.594, 1.687)

0.997

1.153 (0.616, 2.159)

0.791

AgeAccelGrim2 T3

1.802 (1.194, 2.720)

0.005

1.815 (1.065, 3.094)

0.028

1.995 (1.026, 3.878)

0.042

Non-Cardiovascular Death

475 deaths

 

244 deaths

 

231 deaths

 

AgeAccelGrim2 T1

Reference

Reference

Reference

Reference

Reference

Reference

AgeAccelGrim2 T2

1.139 (0.895, 1.449)

0.290

1.029 (0.741, 1.428)

0.865

1.176 (0.829, 1.668)

0.365

AgeAccelGrim2 T2

1.548 (1.192, 2.012)

0.001

1.396 (0.978, 1.993)

0.066

1.450 (0.978, 2.149)

0.065

  1. Cox proportional hazards models were adjusted for chronological age, sex, ethnicity, poverty income ratio, smoking status, body mass index, geriatric nutritional risk index, cardiovascular disease, hypertension, hyperlipidemia, and chronic kidney disease
  2. CI, confidence interval; HR, hazard ratio