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Table 2 Associations between DNAmAA and mortality outcomes among participants with diabetes and pre-diabetes

From: Unveiling the impact of DNA-methylation age acceleration on mortality risk in diabetes and pre-diabetes: insights from the US NHANES program

 

Overall participants

Participants with diabetes

Participants with pre-diabetes

 

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Overall survival

662 deaths

 

347 deaths

 

315 deaths

 

HorvathAge Accel

1.072 (0.998, 1.151)

0.056

1.035 (0.939, 1.142)

0.485

1.094 (0.985, 1.215)

0.092

HannumAge Accel

1.081 (1.003, 1.165)

0.042

1.046 (0.947, 1.156)

0.375

1.090 (0.973, 1.220)

0.140

SkinBloodAge Accel

0.995 (0.920, 1.075)

0.898

0.972 (0.881, 1.073)

0.580

0.990 (0.876, 1.119)

0.872

PhenoAge Accel

1.106 (1.043, 1.173)

0.001

1.039 (0.962, 1.122)

0.332

1.184 (1.080, 1.299)

 < 0.001

AgeAccelGrim2

1.354 (1.230, 1.491)

 < 0.001

1.309 (1.142, 1.500)

 < 0.001

1.345 (1.171, 1.545)

 < 0.001

ZhangAge Accel

1.102 (0.879, 1.381)

0.401

0.996 (0.753, 1.316)

0.976

1.170 (0.813, 1.685)

0.398

LinAge Accel

1.018 (0.968, 1.071)

0.494

0.988 (0.923, 1.057)

0.722

1.038 (0.960, 1.122)

0.347

WeidnerAge Accel

1.004 (0.960, 1.051)

0.847

1.002 (0.937, 1.071)

0.954

1.020 (0.958, 1.087)

0.528

Vidal-BraloAge Accel

1.098 (1.016, 1.186)

0.018

1.083 (0.973, 1.207)

0.145

1.114 (0.994, 1.250)

0.064

DunedinPoAm

1.157 (1.055, 1.270)

0.002

1.096 (0.967, 1.243)

0.150

1.184 (1.032, 1.358)

0.016

Cardiovascular death

187 deaths

 

103 deaths

 

84 deaths

 

HorvathAge Accel

0.990 (0.868, 1.129)

0.880

1.068 (0.893, 1.278)

0.470

0.827 (0.672, 1.016)

0.071

HannumAge Accel

1.052 (0.914, 1.211)

0.478

1.032 (0.863, 1.235)

0.728

1.015 (0.812, 1.270)

0.893

SkinBloodAge Accel

0.998 (0.863, 1.153)

0.973

1.007 (0.835, 1.215)

0.941

0.898 (0.718, 1.124)

0.347

PhenoAge Accel

1.105 (0.987, 1.237)

0.082

1.081 (0.938, 1.246)

0.284

1.097 (0.910, 1.322)

0.330

AgeAccelGrim2

1.501 (1.252, 1.799)

 < 0.001

1.411 (1.100, 1.810)

0.007

1.524 (1.169, 1.985)

0.002

ZhangAge Accel

0.984 (0.663, 1.458)

0.935

0.981 (0.601, 1.600)

0.937

0.794 (0.427, 1.475)

0.466

LinAge Accel

0.991 (0.901, 1.090)

0.853

1.006 (0.889, 1.137)

0.929

0.910 (0.779, 1.064)

0.239

WeidnerAge Accel

1.014 (0.933, 1.102)

0.742

1.036 (0.915, 1.172)

0.578

1.003 (0.887, 1.133)

0.966

Vidal-BraloAge Accel

1.005 (0.870, 1.160)

0.948

1.041 (0.858, 1.264)

0.682

0.911 (0.723, 1.147)

0.429

DunedinPoAm

1.235 (1.041, 1.465)

0.160

1.062 (0.842, 1.340)

0.609

1.357 (1.054, 1.747)

0.018

Non-cardiovascular death

475 deaths

 

244 deaths

 

231 deaths

 

HorvathAge Accel

1.103 (1.015, 1.200)

0.022

1.020 (0.907, 1.147)

0.741

1.200 (1.065, 1.352)

0.003

HannumAge Accel

1.091 (0.998, 1.192)

0.054

1.047 (0.929, 1.182)

0.451

1.118 (0.980, 1.275)

0.096

SkinBloodAge Accel

0.991 (0.904, 1.087)

0.855

0.955 (0.851, 1.072)

0.437

1.022 (0.884, 1.182)

0.765

PhenoAge Accel

1.103 (1.029, 1.182)

0.006

1.018 (0.928, 1.117)

0.702

1.207 (1.085, 1.342)

0.001

AgeAccelGrim2

1.299 (1.160, 1.456)

 < 0.001

1.263 (1.073, 1.486)

0.005

1.288 (1.095, 1.515)

0.002

ZhangAge Accel

1.147 (0.874, 1.506)

0.323

0.992 (0.708, 1.390)

0.964

1.358 (0.874, 2.110)

0.173

LinAge Accel

1.027 (0.968, 1.090)

0.372

0.979 (0.902, 1.063)

0.618

1.082 (0.990, 1.184)

0.083

WeidnerAge Accel

0.999 (0.946, 1.054)

0.957

0.987 (0.911, 1.069)

0.747

1.024 (0.951, 1.103)

0.524

Vidal-BraloAge Accel

1.134 (1.035, 1.243)

0.007

1.100 (0.966, 1.252)

0.149

1.195 (1.047, 1.364)

0.008

DunedinPoAm

1.130 (1.012, 1.261)

0.030

1.112 (0.958, 1.290)

0.163

1.120 (0.952, 1.318)

0.173

  1. Cox proportional hazards models were adjusted for chronological age, sex, ethnicity, poverty income ratio, smoking status, body mass index, geriatric nutritional risk index, cardiovascular disease, hypertension, hyperlipidemia, and chronic kidney disease
  2. Bold indicates significant at P < 0.05
  3. CI, confidence interval; DNAmAA, DNA-methylation age acceleration; HR, hazard ratio
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Clinical Epigenetics

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