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Table 2 Comparison of relative IC50 between NAT1high and NAT1low groups

From: Investigating the mechanisms by which low NAT1 expression in tumor cells contributes to chemo-resistance in colorectal cancer

Database

Drugs (IC50)

NAT1_low (N = 296)

NAT1_high (N = 296)

Fold change

P value

GDSC_V1

Daporinad_1248

0.20 ± 0.72

0.08 ± 0.12

0.397303447

0.004357953

GDSC_V2

Vincristine_1818

0.47 ± 0.91

0.20 ± 0.25

0.425308419

9.58337E-07

GDSC_V2

Gemcitabine_1190

1.55 ± 2.62

0.68 ± 1.09

0.440790109

2.09078E-07

GDSC_V2

Docetaxel_1819

0.29 ± 0.51

0.14 ± 0.20

0.472369513

1.56627E-06

GDSC_V2

Vinblastine_1004

0.06 ± 0.10

0.03 ± 0.04

0.473404913

1.09105E-06

GDSC_V1

Gemcitabine_135

0.18 ± 0.23

0.10 ± 0.16

0.547522731

6.26625E-07

GDSC_V2

YK-4-279_1239

17.78 ± 19.09

9.76 ± 10.37

0.549208082

4.43499E-10

GDSC_V2

Pevonedistat_1529

3.86 ± 5.34

2.12 ± 2.12

0.550279084

2.91587E-07

GDSC_V2

Vinorelbine_2048

0.09 ± 0.13

0.05 ± 0.08

0.566325708

2.46423E-06

GDSC_V2

KRAS (G12C) Inhibitor-12_1855

129.49 ± 110.22

74.12 ± 61.28

0.572363494

1.60819E-13

GDSC_V1

PLK_6522_1451

0.15 ± 0.46

0.09 ± 0.09

0.578548545

0.016226363

GDSC_V2

Cytarabine_1006

9.78 ± 8.68

5.85 ± 8.29

0.597889224

2.66787E-08

GDSC_V1

ARRY-520_474

0.10 ± 0.10

0.06 ± 0.07

0.599251363

1.38231E-07

GDSC_V1

Ispinesib Mesylate_208

0.22 ± 0.24

0.13 ± 0.11

0.608238084

1.83669E-08

GDSC_V1

AZD4877_1409

0.04 ± 0.04

0.03 ± 0.02

0.610253366

2.61266E-09

GDSC_V2

Docetaxel_1007

0.02 ± 0.02

0.01 ± 9.5e-3

0.613821245

2.25472E-10

GDSC_V2

Mitoxantrone_1810

3.31 ± 3.03

2.05 ± 2.01

0.619296618

4.2026E-09

GDSC_V2

AZD5438_1401

14.02 ± 14.25

8.71 ± 9.32

0.62121301

1.15855E-07

GDSC_V2

Dinaciclib_1180

0.09 ± 0.25

0.06 ± 0.03

0.634598278

0.019359769

GDSC_V2

Trametinib_1372

2.93 ± 3.19

1.86 ± 1.41

0.635035452

1.81855E-07

GDSC_V2

5-Fluorouracil_1073

195.90 ± 165.46

124.57 ± 195.72

0.635917282

2.1338E-06

GDSC_V2

Dactinomycin_1811

0.13 ± 0.07

0.08 ± 0.05

0.641649302

2.19666E-16

GDSC_V2

Irinotecan_1088

21.85 ± 19.37

14.02 ± 11.35

0.641771455

3.45048E-09

GDSC_V2

Camptothecin_1003

0.15 ± 0.14

0.09 ± 0.08

0.641825954

3.95048E-08

GDSC_V2

Eg5_9814_1712

0.08 ± 0.08

0.05 ± 0.06

0.648021519

4.93084E-07

GDSC_V2

Teniposide_1809

2.89 ± 2.52

1.87 ± 1.68

0.648712054

1.35274E-08

GDSC_V2

Alisertib_1051

11.96 ± 10.25

7.80 ± 7.41

0.651939165

2.3292E-08

GDSC_V2

Paclitaxel_1080

0.11 ± 0.13

0.08 ± 0.13

0.655343737

0.000266396