Skip to main content

Table 3 Variance components derived from age-moderated univariate models

From: Genetic and environmental contributions to epigenetic aging across adolescence and young adulthood

Epigenetic aging measure

Age group

A (%)

C/D (%)

E (%)

V

Horvath Accel.

(ACE model with moderated a and e effects)

9.5

1.59 (18)

3.04 (35)

4.18 (47)

8.82

12

2.20 (22)

3.04 (30)

4.90 (48)

10.14

15.5

3.20 (26)

3.04 (25)

6.00 (49)

12.24

18

4.03 (29)

3.04 (22)

6.85 (49)

13.92

21.5

5.36 (32)

3.04 (19)

8.14 (49)

16.54

24

6.42 (35)

3.04 (16)

9.13 (49)

18.59

27.5

8.08 (37)

3.04 (14)

10.60 (49)

21.72

30

9.37 (39)

3.04 (12)

11.73 (49)

24.14

PedBE Accel.

(ACE model with moderated e effect)

9.5

0.16 (18)

0.43 (49)

0.29 (33)

0.88

12

0.16 (16)

0.43 (45)

0.37 (39)

0.96

15.5

0.16 (14)

0.43 (40)

0.50 (46)

1.09

18

0.16 (13)

0.43 (36)

0.60 (51)

1.19

21.5

0.16 (11)

0.43 (32)

0.76 (57)

1.35

24

0.16 (11)

0.43 (29)

0.89 (60)

1.48

27.5

0.16 (9)

0.43 (26)

1.08 (65)

1.67

30

0.16 (8)

0.43 (24)

1.23 (68)

1.82

GrimAge Accel.

(AE model with moderated a effect)

9.5

1.17 (24)

–

3.78 (76)

4.95

12

1.33 (26)

–

3.78 (74)

5.11

15.5

1.57 (29)

–

3.78 (71)

5.35

18

1.76 (32)

–

3.78 (68)

5.54

21.5

2.04 (35)

–

3.78 (65)

5.82

24

2.25 (37)

–

3.78 (63)

6.03

27.5

2.57 (40)

–

3.78 (60)

6.35

30

2.81 (43)

–

3.78 (57)

6.59

DunedinPACE

(ADE model with moderated d effect)

9.5

0.002 (32)

0.001 (10)

0.003 (58)

0.005

12

0.002 (30)

0.001 (13)

0.003 (57)

0.006

15.5

0.002 (29)

0.001 (17)

0.003 (54)

0.006

18

0.002 (28)

0.001 (20)

0.003 (52)

0.006

21.5

0.002 (27)

0.001 (24)

0.003 (49)

0.006

24

0.002 (26)

0.002 (27)

0.003 (47)

0.007

27.5

0.002 (24)

0.002 (31)

0.003 (45)

0.007

30

0.002 (23)

0.002 (34)

0.003 (43)

0.007

  1. The estimates are derived from the best-fitting univariate models with age moderation of genetic and environmental components of the four epigenetic aging measures, which are depicted in parentheses
  2. A (%), component due to additive genetic factors; D (%), component due to non-additive genetic factors; C (%), component due to shared environmental factors; E (%), component due to individually unique environmental factors including measurement error; V, total variance; Accel., Acceleration
  3. Components that are significantly moderated by age are shown in bold