Fig. 7

A five-CpG signature can discern PMF from other malignancies and controls. a, b The DNAm levels at five CpGs (cg02210934, cg02739280, cg21708058, cg07197092, and cg08069247) were combined into a simple PMF score (PMF score = 5—sum of the five DNAm values). The PMF score is provided for datasets of the a) training set, and b) independent validation set. The datasets of PMF, other myeloid malignancies and healthy samples used from both our and public datasets are indicated with GSE numbers. c The PMF score did not correlate with mutation allele burden. d Box plot demonstrating that the driver mutations did not have significant impact on the PMF score. However, triple negative (TN) samples of publicly available PMF datasets (GSE152519) revealed a lower PMF score. Statistical significance was determined using an unpaired t-test