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Fig. 2 | Clinical Epigenetics

Fig. 2

From: DNA methylation in primary myelofibrosis is partly associated with driver mutations and distinct from other myeloid malignancies

Fig. 2

Changes in DNA methylation according to driver mutations. a-c Scatter plots illustrating the mean DNAm beta values in PMF patients compared to healthy controls, stratified by driver mutation: a) JAK2 mutation, b) CALR mutation, and c) MPL mutation. d-f Additional scatter plots comparing the mean DNAm beta values of PMF patients based on their driver mutation: d) CALR versus JAK2; e) MPL versus JAK2; and f) MPL versus CALR. Significant hypo- and hypermethylated CpGs are indicated in blue and red, respectively (mean DNAm difference > 20%; adjusted p-values < 0.05). g Comparison of significantly differentially methylated CpGs between JAK2 and MPL versus CALR and MPL, with gene names for overlapping CpGs highlighted

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Clinical Epigenetics

ISSN: 1868-7083

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