Fig. 4

Whole-Genome Bisulfite Sequencing (WGBS) analysis of atrial tissues from the Donor and Recipient groups. A Violin plots showing the global DNA methylation levels of CpG sites in recipient hearts compared to donors. (n = 5 samples per group, ***P < 0.001). B Methylation levels across various genomic functional regions in Recipient versus Donor. C Methylation patterns of the gene body, 2 kb upstream of the transcription start site (TSS) and 2 kb downstream of the transcription end site (TES) in each group. D The ratio of hypermethylated and hypomethylated Differentially Methylated Regions (DMRs) in Recipient versus Donor. E Proportions of DMRs located in different genomic features. F The distribution of DMRs across the whole-genome. G and H GO-BP enrichment (G, left) and KEGG analysis (H, right) of DMR-related Genes (DMGs)