Table 6 MR-PRESSO results of the MR analysis
Outcome | Exposure | Raw | Outlier corrected | Global p | Outliers | Distortion p | ||
|---|---|---|---|---|---|---|---|---|
OR_CI | P | OR_CI | P | Â | Â | Â | ||
Circulating plasma alpha-Klotho levels | Arterial embolism and thrombosis of lower extremity artery | 0.9719 (0.9121–1.0356) | 0.4128 | NA (NA–NA) | NA | 0.61 |  |  |
Fibroblast growth factor 23 levels | Arterial embolism and thrombosis of lower extremity artery | 0.9879 (0.967–1.0094) | 0.2994 | NA (NA–NA) | NA | 0.885 |  | NA |
Granulocyte proportions | Arterial embolism and thrombosis of lower extremity artery | 0.9989 (0.9967–1.0012) | 0.3754 | NA (NA–NA) | NA | 0.275 |  |  |
GrimAge | Arterial embolism and thrombosis of lower extremity artery | 0.9643 (0.8565–1.0858) | 0.5649 | NA (NA–NA) | NA | 0.06 |  |  |
HannumAge | Arterial embolism and thrombosis of lower extremity artery | 0.9907 (0.9192–1.0678) | 0.8132 | NA (NA–NA) | NA | 0.576 |  | NA |
IEAA | Arterial embolism and thrombosis of lower extremity artery | 1.0111 (0.9612–1.0636) | 0.6798 | NA (NA–NA) | NA | 0.93 |  | NA |
PAI1 | Arterial embolism and thrombosis of lower extremity artery | 1.0438 (0.8351–1.3046) | 0.7161 | NA (NA–NA) | NA | 0.446 |  |  |
PhenoAge | Arterial embolism and thrombosis of lower extremity artery | 0.9265 (0.8319–1.0318) | 0.202 | NA (NA–NA) | NA | 0.484 |  |  |
Telomere length | Arterial embolism and thrombosis of lower extremity artery | 0.9996 (0.9919–1.0073) | 0.9201 | NA (NA–NA) | NA | 0.047 | NA | NA |
Circulating plasma alpha-Klotho levels | DVT of lower extremities | 1.0393 (0.9795–1.1027) | 0.2284 | NA (NA–NA) | NA | 0.546 |  |  |
Fibroblast growth factor 23 levels | DVT of lower extremities | 1.0283 (0.9748–1.0846) | 0.3263 | 0.9915 (0.9651–1.0187) | 0.5492 | 0.004 | rs80136276 | 0.011 |
Granulocyte proportions | DVT of lower extremities | 1.0022 (0.9997–1.0046) | 0.1128 | NA (NA–NA) | NA | 0.273 |  |  |
GrimAge | DVT of lower extremities | 1.0275 (0.9194–1.1482) | 0.6413 | NA (NA–NA) | NA | 0.203 |  |  |
HannumAge | DVT of lower extremities | 0.9714 (0.8359–1.129) | 0.7121 | 1.0428 (0.8939–1.2166) | 0.6045 | 0.01 | rs80260619 | 0.217 |
IEAA | DVT of lower extremities | 0.9658 (0.8312–1.1221) | 0.6572 | 0.9375 (0.8222–1.0691) | 0.3562 | 0.016 | rs17543805 | 0.787 |
PAI1 | DVT of lower extremities | 1.1308 (0.7927–1.6131) | 0.5105 | NA (NA–NA) | NA | 0.101 |  |  |
PhenoAge | DVT of lower extremities | 0.9509 (0.8331–1.0854) | 0.4703 | NA (NA–NA) | NA | 0.359 |  |  |
Telomere length | DVT of lower extremities | 1.0059 (0.9968–1.015) | 0.2249 | 1.0038 (0.9971–1.0105) | 0.2917 | 0.017 | rs10886430 | 0.298 |
Circulating plasma alpha-Klotho levels | Other arterial embolism and thrombosis | 0.9667 (0.8984–1.0402) | 0.4164 | NA (NA–NA) | NA | 0.562 |  |  |
Fibroblast growth factor 23 levels | Other arterial embolism and thrombosis | 0.9888 (0.9464–1.0331) | 0.6372 | NA (NA–NA) | NA | 0.219 |  | NA |
Granulocyte proportions | Other arterial embolism and thrombosis | 0.9984 (0.9952–1.0015) | 0.3503 | NA (NA–NA) | NA | 0.208 |  |  |
GrimAge | Other arterial embolism and thrombosis | 1.0128 (0.8887–1.1542) | 0.8564 | NA (NA–NA) | NA | 0.235 |  |  |
HannumAge | Other arterial embolism and thrombosis | 0.9308 (0.8054–1.0757) | 0.3759 | NA (NA–NA) | NA | 0.109 |  | NA |
IEAA | Other arterial embolism and thrombosis | 0.9293 (0.8087–1.0679) | 0.3487 | NA (NA–NA) | NA | 0.194 |  | NA |
PAI1 | Other arterial embolism and thrombosis | 1.0536 (0.8101–1.3704) | 0.7129 | NA (NA–NA) | NA | 0.551 |  |  |
PhenoAge | Other arterial embolism and thrombosis | 1.0475 (0.9552–1.1486) | 0.3694 | NA (NA–NA) | NA | 0.809 |  |  |
Telomere length | Other arterial embolism and thrombosis | 1.0003 (0.9888–1.0119) | 0.9631 | 0.9958 (0.9875–1.0043) | 0.3874 | 0.031 | rs12957035 | 0.353 |
Circulating plasma alpha-Klotho levels | Phlebitis and thrombophlebitis | 1.0169 (0.9452–1.094) | 0.664 | NA (NA–NA) | NA | 0.539 |  |  |
Fibroblast growth factor 23 levels | Phlebitis and thrombophlebitis | 1.0376 (0.9677–1.1125) | 0.3241 | 0.9938 (0.9583–1.0305) | 0.7436 | 0.003 | rs80136276 | 0.002 |
Granulocyte proportions | Phlebitis and thrombophlebitis | 1.0016 (0.9985–1.0047) | 0.3319 | NA (NA–NA) | NA | 0.217 |  |  |
GrimAge | Phlebitis and thrombophlebitis | 0.9842 (0.8447–1.1467) | 0.8422 | NA (NA–NA) | NA | 0.094 |  |  |
HannumAge | Phlebitis and thrombophlebitis | 0.9402 (0.7723–1.1445) | 0.5525 | 0.9111 (0.7628–1.0882) | 0.3311 | 0.004 | rs17543805 | 0.822 |
IEAA | Phlebitis and thrombophlebitis | 0.9902 (0.8193–1.1966) | 0.9204 | NA (NA–NA) | NA | 0.017 | NA | NA |
PAI1 | Phlebitis and thrombophlebitis | 1.0786 (0.7051–1.65) | 0.7343 | NA (NA–NA) | NA | 0.212 |  |  |
PhenoAge | Phlebitis and thrombophlebitis | 0.9279 (0.7931–1.0855) | 0.3719 | NA (NA–NA) | NA | 0.381 |  |  |
Telomere length | Phlebitis and thrombophlebitis | 1.007 (0.998–1.0161) | 0.1581 | NA (NA–NA) | NA | 0.135 |  | NA |
Circulating plasma alpha-Klotho levels | Portal vein thrombosis | 1.0169 (0.9452–1.094) | 0.664 | NA (NA–NA) | NA | 0.539 |  |  |
Fibroblast growth factor 23 levels | Portal vein thrombosis | 1.0334 (1.0074–1.06) | 0.0854 | NA (NA–NA) | NA | 0.69 |  | NA |
Granulocyte proportions | Portal vein thrombosis | 1.0009 (0.9989–1.0029) | 0.4515 | NA (NA–NA) | NA | 0.496 |  |  |
GrimAge | Portal vein thrombosis | 1.015 (0.9339–1.1032) | 0.7486 | NA (NA–NA) | NA | 0.542 |  |  |
HannumAge | Portal vein thrombosis | 0.967 (0.894–1.0458) | 0.4626 | NA (NA–NA) | NA | 0.63 |  | NA |
IEAA | Portal vein thrombosis | 0.9914 (0.9503–1.0342) | 0.7146 | NA (NA–NA) | NA | 0.923 |  | NA |
PAI1 | Portal vein thrombosis | 1.2439 (0.9161–1.6891) | 0.2564 | NA (NA–NA) | NA | 0.594 |  |  |
PhenoAge | Portal vein thrombosis | 0.871 (0.7898–0.9604) | 0.0696 | NA (NA–NA) | NA | 0.694 |  |  |
Telomere length | Portal vein thrombosis | 1.007 (0.998–1.0161) | 0.1581 | NA (NA–NA) | NA | 0.135 |  | NA |
Circulating plasma alpha-Klotho levels | Pulmonary embolism | 1.079 (0.9822–1.1853) | 0.1388 | NA (NA–NA) | NA | 0.33 |  |  |
Fibroblast growth factor 23 levels | Pulmonary embolism | 1.0353 (0.9614–1.115) | 0.3729 | 0.9902 (0.9423–1.0406) | 0.7037 |  < 0.001 | rs74739952 | 0.051 |
Granulocyte proportions | Pulmonary embolism | 1.0035 (1.0003–1.0067) | 0.0485 | NA (NA–NA) | NA | 0.272 |  |  |
GrimAge | Pulmonary embolism | 1.0548 (0.9322–1.1936) | 0.4127 | NA (NA–NA) | NA | 0.523 |  |  |
HannumAge | Pulmonary embolism | 1.0049 (0.8433–1.1976) | 0.9568 | NA (NA–NA) | NA | 0.011 | NA | NA |
IEAA | Pulmonary embolism | 0.9058 (0.7861–1.0437) | 0.1943 | NA (NA–NA) | NA | 0.255 |  | NA |
PAI1 | Pulmonary embolism | 1.2662 (0.9027–1.7762) | 0.1948 | NA (NA–NA) | NA | 0.345 |  |  |
PhenoAge | Pulmonary embolism | 0.9269 (0.7923–1.0842) | 0.3598 | NA (NA–NA) | NA | 0.441 |  |  |
Telomere length | Pulmonary embolism | 1.0059 (0.9961–1.0158) | 0.257 | NA (NA–NA) | NA | 0.138 |  | NA |
Circulating plasma alpha-Klotho levels | Venous thromboembolism | 1.0624 (0.9725–1.1607) | 0.1904 | NA (NA–NA) | NA | 0.077 |  |  |
Fibroblast growth factor 23 levels | Venous thromboembolism | 1.02 (0.974–1.0681) | 0.4062 | 0.9806 (0.9502–1.012) | 0.2327 | 0.007 | rs2428493 | 0.108 |
Granulocyte proportions | Venous thromboembolism | 1.0023 (0.9991–1.0054) | 0.1665 | NA (NA–NA) | NA | 0.051 |  |  |
GrimAge | Venous thromboembolism | 1.164 (1.0467–1.2943) | 0.0088 | NA (NA–NA) | NA | 0.822 |  |  |
HannumAge | Venous thromboembolism | 0.9604 (0.8277–1.1145) | 0.5985 | NA (NA–NA) | NA | 0.001 | NA | NA |
IEAA | Venous thromboembolism | 1.0043 (0.89–1.1333) | 0.9452 | NA (NA–NA) | NA | 0.235 |  | NA |
PAI1 | Venous thromboembolism | 1.1041 (0.7822–1.5585) | 0.5773 | NA (NA–NA) | NA | 0.122 |  |  |
PhenoAge | Venous thromboembolism | 1.0545 (0.9123–1.2189) | 0.4781 | NA (NA–NA) | NA | 0.358 |  |  |
Telomere length | Venous thromboembolism | 1.0054 (0.9964–1.0145) | 0.2516 | 1.0037 (0.9956–1.0118) | 0.3772 | 0.015 | rs2066865 | 0.48 |