Causal associations between epigenetic age and thromboembolism: a bi-directional two-sample Mendelian randomization study

Jin, Bowen; Li, Yunyan; Li, Dingyang; Jing, Chi; Sheng, Qunshan

doi:10.1186/s13148-025-01875-3

Table 5 Heterogeneity and pleiotropy for each exposure factor on epigenetic aging factors

From: Causal associations between epigenetic age and thromboembolism: a bi-directional two-sample Mendelian randomization study

Outcome	Exposure	Heterogeneity		Pleiotropy
Outcome	Exposure	Q statistic (IVW)	P value	MR Egger Intercept	P value
Circulating plasma alpha-Klotho levels	Pulmonary embolism	13.941	0.304	0.017	0.45
Circulating plasma alpha-Klotho levels	DVT of lower extremities	9.583	0.568	0.023	0.144
Circulating plasma alpha-Klotho levels	Venous thromboembolism	39.763	0.069	0.009	0.425
Circulating plasma alpha-Klotho levels	Phlebitis and thrombophlebitis	6.804	0.558	0.009	0.611
Circulating plasma alpha-Klotho levels	Arterial embolism and thrombosis of lower extremity artery	4.961	0.549	− 0.013	0.607
Circulating plasma alpha-Klotho levels	Portal vein thrombosis	1.689	0.43	− 0.058	0.497
Circulating plasma alpha-Klotho levels	Other arterial embolism and thrombosis	3.025	0.554	− 0.07	0.341
Fibroblast growth factor 23 levels	Pulmonary embolism	42.539	0	− 0.003	0.854
Fibroblast growth factor 23 levels	DVT of lower extremities	33.137	0.001	− 0.004	0.747
Fibroblast growth factor 23 levels	Venous thromboembolism	48.176	0.033	− 0.006	0.257
Fibroblast growth factor 23 levels	Phlebitis and thrombophlebitis	27.716	0.001	0.008	0.608
Fibroblast growth factor 23 levels	Arterial embolism and thrombosis of lower extremity artery	3.829	0.872	− 0.004	0.732
Fibroblast growth factor 23 levels	Portal vein thrombosis	1.568	0.667	0.001	0.964
Fibroblast growth factor 23 levels	Other arterial embolism and thrombosis	7.245	0.203	− 0.003	0.902
Granulocyte proportions	Pulmonary embolism	9.844	0.545	0.001	0.168
Granulocyte proportions	DVT of lower extremities	8.915	0.54	0	0.887
Granulocyte proportions	Venous thromboembolism	40.334	0.062	0	0.297
Granulocyte proportions	Phlebitis and thrombophlebitis	4.876	0.675	− 0.001	0.289
Granulocyte proportions	Arterial embolism and thrombosis of lower extremity artery	10.2	0.251	0	0.802
Granulocyte proportions	Portal vein thrombosis	2.441	0.486	0.002	0.274
Granulocyte proportions	Other arterial embolism and thrombosis	7.993	0.157	− 0.001	0.755
GrimAge	Pulmonary embolism	12.385	0.496	0.027	0.38
GrimAge	DVT of lower extremities	14.747	0.256	0.048	0.064
GrimAge	Venous thromboembolism	20.183	0.858	0.011	0.481
GrimAge	Phlebitis and thrombophlebitis	15.863	0.07	0.009	0.813
GrimAge	Arterial embolism and thrombosis of lower extremity artery	15.457	0.051	0.01	0.831
GrimAge	Portal vein thrombosis	2.07	0.558	− 0.053	0.538
GrimAge	Other arterial embolism and thrombosis	7.313	0.198	− 0.055	0.437
HannumAge	Pulmonary embolism	17.792	0.087	0.005	0.913
HannumAge	DVT of lower extremities	25.533	0.004	0.051	0.19
HannumAge	Venous thromboembolism	54.387	0.002	0.024	0.21
HannumAge	Phlebitis and thrombophlebitis	23.866	0.001	0.051	0.315
HannumAge	Arterial embolism and thrombosis of lower extremity artery	6.519	0.589	0.003	0.929
HannumAge	Portal vein thrombosis	1.906	0.592	0.081	0.364
HannumAge	Other arterial embolism and thrombosis	9.34	0.096	− 0.016	0.84
IEAA	Pulmonary embolism	16.071	0.245	− 0.051	0.125
IEAA	DVT of lower extremities	26.562	0.009	0	0.999
IEAA	Venous thromboembolism	35.25	0.196	0.013	0.383
IEAA	Phlebitis and thrombophlebitis	24.284	0.004	0.037	0.427
IEAA	Arterial embolism and thrombosis of lower extremity artery	2.808	0.946	− 0.031	0.347
IEAA	Portal vein thrombosis	0.521	0.914	− 0.024	0.77
IEAA	Other arterial embolism and thrombosis	8.088	0.151	− 0.027	0.731
PAI1	Pulmonary embolism	15.118	0.3	0.197	0.025
PAI1	DVT of lower extremities	19.789	0.071	− 0.115	0.318
PAI1	Venous thromboembolism	40.822	0.071	− 0.062	0.176
PAI1	Phlebitis and thrombophlebitis	15.141	0.087	− 0.173	0.223
PAI1	Arterial embolism and thrombosis of lower extremity artery	7.956	0.438	0.149	0.1
PAI1	Portal vein thrombosis	2.546	0.467	− 0.186	0.588
PAI1	Other arterial embolism and thrombosis	3.908	0.563	− 0.093	0.69
PhenoAge	Pulmonary embolism	12.591	0.48	0.001	0.971
PhenoAge	DVT of lower extremities	12.868	0.379	0.039	0.231
PhenoAge	Venous thromboembolism	30.576	0.386	0.05	0.007
PhenoAge	Phlebitis and thrombophlebitis	10.274	0.329	0.038	0.317
PhenoAge	Arterial embolism and thrombosis of lower extremity artery	7.999	0.434	− 0.02	0.636
PhenoAge	Portal vein thrombosis	1.698	0.637	0.072	0.521
PhenoAge	Other arterial embolism and thrombosis	2.229	0.817	− 0.02	0.784
Telomere length	Pulmonary embolism	22.069	0.077	0.002	0.576
Telomere length	DVT of lower extremities	28.926	0.004	0.001	0.618
Telomere length	Venous thromboembolism	49.55	0.01	− 0.001	0.61
Telomere length	Phlebitis and thrombophlebitis	14.474	0.106	0.002	0.311
Telomere length	Arterial embolism and thrombosis of lower extremity artery	16.971	0.03	− 0.003	0.288
Telomere length	Portal vein thrombosis	2.361	0.307	0	0.984
Telomere length	Other arterial embolism and thrombosis	14.713	0.012	0.001	0.935

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