Causal associations between epigenetic age and thromboembolism: a bi-directional two-sample Mendelian randomization study

Jin, Bowen; Li, Yunyan; Li, Dingyang; Jing, Chi; Sheng, Qunshan

doi:10.1186/s13148-025-01875-3

Table 2 Heterogeneity and pleiotropy for each exposure factor on thromboembolism

From: Causal associations between epigenetic age and thromboembolism: a bi-directional two-sample Mendelian randomization study

Outcome	Exposure	Heterogeneity		Pleiotropy
Outcome	Exposure	Q statistic (IVW)	P value	MR Egger Intercept	P value
Arterial embolism and thrombosis of lower extremity artery	Circulating plasma alpha-Klotho levels	12.791	0.012	− 0.003	0.981
DVT of lower extremities	Circulating plasma alpha-Klotho levels	62.882	0	− 0.137	0.179
Other arterial embolism and thrombosis	Circulating plasma alpha-Klotho levels	2.39	0.665	0	0.996
Phlebitis and thrombophlebitis	Circulating plasma alpha-Klotho levels	42.713	0	− 0.117	0.105
Portal vein thrombosis	Circulating plasma alpha-Klotho levels	4.109	0.392	− 0.083	0.488
Pulmonary embolism	Circulating plasma alpha-Klotho levels	27.934	0	− 0.064	0.27
Venous thromboembolism	Circulating plasma alpha-Klotho levels	84.111	0	− 0.086	0.208
Arterial embolism and thrombosis of lower extremity artery	Fibroblast growth factor 23 levels	9.812	0.199	0.032	0.706
DVT of lower extremities	Fibroblast growth factor 23 levels	270.753	0	0.057	0.751
Other arterial embolism and thrombosis	Fibroblast growth factor 23 levels	5.353	0.617	0.007	0.927
Phlebitis and thrombophlebitis	Fibroblast growth factor 23 levels	221.154	0	0.074	0.618
Portal vein thrombosis	Fibroblast growth factor 23 levels	6.077	0.531	− 0.087	0.43
Pulmonary embolism	Fibroblast growth factor 23 levels	160.509	0	0.053	0.638
Venous thromboembolism	Fibroblast growth factor 23 levels	467.86	0	0.055	0.682
Arterial embolism and thrombosis of lower extremity artery	Granulocyte proportions	23.46	0.102	− 0.021	0.676
DVT of lower extremities	Granulocyte proportions	17.037	0.383	0.007	0.692
Other arterial embolism and thrombosis	Granulocyte proportions	24.411	0.081	− 0.076	0.172
Phlebitis and thrombophlebitis	Granulocyte proportions	20.557	0.196	− 0.029	0.094
Portal vein thrombosis	Granulocyte proportions	29.996	0.018	− 0.105	0.254
Pulmonary embolism	Granulocyte proportions	10.628	0.832	− 0.004	0.745
Venous thromboembolism	Granulocyte proportions	20.761	0.188	− 0.005	0.629
Arterial embolism and thrombosis of lower extremity artery	GrimAge	3.764	0.288	− 0.512	0.301
DVT of lower extremities	GrimAge	5.394	0.145	0.028	0.922
Other arterial embolism and thrombosis	GrimAge	0.808	0.848	0.065	0.889
Phlebitis and thrombophlebitis	GrimAge	5.399	0.145	0.188	0.42
portal vein thrombosis	GrimAge	7.183	0.066	− 1.03	0.368
Pulmonary embolism	GrimAge	0.82	0.845	− 0.051	0.718
Venous thromboembolism	GrimAge	3.85	0.278	− 0.026	0.85
Arterial embolism and thrombosis of lower extremity artery	HannumAge	6.343	0.609	0.055	0.454
DVT of lower extremities	HannumAge	2.047	0.98	− 0.007	0.819
Other arterial embolism and thrombosis	HannumAge	6.71	0.568	− 0.014	0.858
Phlebitis and thrombophlebitis	HannumAge	9.683	0.288	− 0.042	0.157
portal vein thrombosis	HannumAge	4.321	0.827	0.009	0.942
Pulmonary embolism	HannumAge	6.844	0.554	0.04	0.128
Venous thromboembolism	HannumAge	2.248	0.972	0.008	0.658
Arterial embolism and thrombosis of lower extremity artery	IEAA	22.951	0.464	− 0.014	0.6
DVT of lower extremities	IEAA	16.678	0.825	− 0.001	0.906
Other arterial embolism and thrombosis	IEAA	27.255	0.245	− 0.006	0.843
Phlebitis and thrombophlebitis	IEAA	41.12	0.011	− 0.002	0.86
portal vein thrombosis	IEAA	22.665	0.48	0.031	0.459
Pulmonary embolism	IEAA	30.899	0.125	0.006	0.557
Venous thromboembolism	IEAA	34.529	0.058	0.003	0.691
Arterial embolism and thrombosis of lower extremity artery	PAI1	5.515	0.238	0.24	0.351
DVT of lower extremities	PAI1	2.157	0.707	0.004	0.96
Other arterial embolism and thrombosis	PAI1	3.731	0.444	0.296	0.256
Phlebitis and thrombophlebitis	PAI1	6.954	0.138	0.131	0.202
Portal vein thrombosis	PAI1	4.28	0.369	0.049	0.904
Pulmonary embolism	PAI1	2.432	0.657	− 0.086	0.27
Venous thromboembolism	PAI1	0.176	0.996	− 0.012	0.812
Arterial embolism and thrombosis of lower extremity artery	PhenoAge	20.1	0.028	0.061	0.441
DVT of lower extremities	PhenoAge	6.61	0.762	0.014	0.537
Other arterial embolism and thrombosis	PhenoAge	10.764	0.376	− 0.054	0.403
Phlebitis and thrombophlebitis	PhenoAge	7.619	0.666	0.018	0.4
Portal vein thrombosis	PhenoAge	16.774	0.08	0.059	0.627
Pulmonary embolism	PhenoAge	10.925	0.363	0.004	0.83
Venous thromboembolism	PhenoAge	7.614	0.667	0.009	0.489
Arterial embolism and thrombosis of lower extremity artery	Telomere length	163.435	0.022	0.007	0.467
DVT of lower extremities	Telomere length	144.202	0.17	0.003	0.391
Other arterial embolism and thrombosis	Telomere length	155.466	0.056	0.003	0.765
Phlebitis and thrombophlebitis	Telomere length	152.703	0.076	0.004	0.268
Portal vein thrombosis	Telomere length	101.641	0.964	− 0.005	0.724
Pulmonary embolism	Telomere length	200.123	0	0	0.937
Venous thromboembolism	Telomere length	246.465	0	0	0.896

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