Causal associations between epigenetic age and thromboembolism: a bi-directional two-sample Mendelian randomization study

Jin, Bowen; Li, Yunyan; Li, Dingyang; Jing, Chi; Sheng, Qunshan

doi:10.1186/s13148-025-01875-3

Table 1 Causal estimates of epigenetic aging factors on thromboembolism

From: Causal associations between epigenetic age and thromboembolism: a bi-directional two-sample Mendelian randomization study

Outcome	Exposure	N.SNP	Methods	OR_CI	P value
Arterial embolism and thrombosis of lower extremity artery	PAI1	5	Inverse variance weighted	1.0001 (0.9998–1.0004)	0.5369
Arterial embolism and thrombosis of lower extremity artery	PAI1	5	MR Egger	0.9998 (0.9991–1.0004)	0.5215
Arterial embolism and thrombosis of lower extremity artery	PAI1	5	Weighted median	0.9999 (0.9996–1.0002)	0.706
Arterial embolism and thrombosis of lower extremity artery	PAI1	5	Weighted mode	0.9999 (0.9994–1.0003)	0.6133
Pulmonary embolism	PAI1	5	Inverse variance weighted	1 (0.9999–1)	0.229
Pulmonary embolism	PAI1	5	MR Egger	1.0001 (0.9999–1.0002)	0.5325
Pulmonary embolism	PAI1	5	Weighted median	0.9999 (0.9998–1)	0.1424
Pulmonary embolism	PAI1	5	Weighted mode	1 (0.9999–1.0001)	0.6384
DVT of lower extremities	PAI1	5	Inverse variance weighted	1 (0.9999–1.0001)	0.4935
DVT of lower extremities	PAI1	5	MR Egger	1 (0.9997–1.0002)	0.756
DVT of lower extremities	PAI1	5	Weighted median	1 (0.9999–1.0001)	0.7119
DVT of lower extremities	PAI1	5	Weighted mode	1 (0.9999–1.0001)	0.8901
Other arterial embolism and thrombosis	PAI1	5	Inverse variance weighted	1.0003 (1–1.0005)	0.0294
Other arterial embolism and thrombosis	PAI1	5	MR Egger	0.9999 (0.9993–1.0005)	0.7654
Other arterial embolism and thrombosis	PAI1	5	Weighted median	1.0003 (0.9999–1.0006)	0.0981
Other arterial embolism and thrombosis	PAI1	5	Weighted mode	1.0002 (0.9999–1.0006)	0.2518
Phlebitis and thrombophlebitis	PAI1	5	Inverse variance weighted	0.9999 (0.9998–1.0001)	0.3214
Phlebitis and thrombophlebitis	PAI1	5	MR Egger	0.9998 (0.9995–1)	0.1429
Phlebitis and thrombophlebitis	PAI1	5	Weighted median	1 (0.9999–1.0001)	0.8411
Phlebitis and thrombophlebitis	PAI1	5	Weighted mode	1 (0.9998–1.0001)	0.6743
Venous thromboembolism	PAI1	5	Inverse variance weighted	1 (0.9999–1)	0.3209
Venous thromboembolism	PAI1	5	MR Egger	1 (0.9999–1.0001)	0.8608
Venous thromboembolism	PAI1	5	Weighted median	1 (0.9999–1)	0.3764
Venous thromboembolism	PAI1	5	Weighted mode	1 (0.9999–1)	0.5273
Portal vein thrombosis	PAI1	5	Inverse variance weighted	1.0002 (0.9998–1.0006)	0.3304
Portal vein thrombosis	PAI1	5	MR Egger	1.0001 (0.9991–1.0012)	0.8249
Portal vein thrombosis	PAI1	5	Weighted median	1.0002 (0.9997–1.0007)	0.4344
Portal vein thrombosis	PAI1	5	Weighted mode	1.0003 (0.9996–1.0009)	0.4585
Arterial embolism and thrombosis of lower extremity artery	HannumAge	9	Inverse variance weighted	1.0563 (0.9162–1.2177)	0.4507
Arterial embolism and thrombosis of lower extremity artery	HannumAge	9	MR Egger	0.8537 (0.4949–1.4728)	0.5875
Arterial embolism and thrombosis of lower extremity artery	HannumAge	9	Weighted median	0.9589 (0.7964–1.1546)	0.658
Arterial embolism and thrombosis of lower extremity artery	HannumAge	9	Weighted mode	0.9521 (0.7647–1.1853)	0.6719
Pulmonary embolism	HannumAge	9	Inverse variance weighted	1.0257 (0.9784–1.0753)	0.2929
Pulmonary embolism	HannumAge	9	MR Egger	0.8792 (0.7333–1.0541)	0.2068
Pulmonary embolism	HannumAge	9	Weighted median	1.0314 (0.9699–1.0968)	0.3242
Pulmonary embolism	HannumAge	9	Weighted mode	1.0205 (0.9382–1.11)	0.6487
DVT of lower extremities	HannumAge	9	Inverse variance weighted	0.9857 (0.9297–1.045)	0.628
DVT of lower extremities	HannumAge	9	MR Egger	1.0119 (0.8084–1.2667)	0.9206
DVT of lower extremities	HannumAge	9	Weighted median	0.9899 (0.9217–1.0632)	0.7807
DVT of lower extremities	HannumAge	9	Weighted mode	0.9908 (0.8982–1.0931)	0.8588
Other arterial embolism and thrombosis	HannumAge	9	Inverse variance weighted	1.0611 (0.9059–1.2429)	0.462
Other arterial embolism and thrombosis	HannumAge	9	MR Egger	1.1217 (0.6111–2.0587)	0.7219
Other arterial embolism and thrombosis	HannumAge	9	Weighted median	1.09 (0.8899–1.3351)	0.4049
Other arterial embolism and thrombosis	HannumAge	9	Weighted mode	1.0774 (0.8196–1.4163)	0.6077
Phlebitis and thrombophlebitis	HannumAge	9	Inverse variance weighted	1.0106 (0.9525–1.0721)	0.7274
Phlebitis and thrombophlebitis	HannumAge	9	MR Egger	1.1894 (0.9655–1.4653)	0.1471
Phlebitis and thrombophlebitis	HannumAge	9	Weighted median	0.9963 (0.9293–1.0682)	0.9178
Phlebitis and thrombophlebitis	HannumAge	9	Weighted mode	0.9937 (0.9059–1.0899)	0.8963
Venous thromboembolism	HannumAge	9	Inverse variance weighted	1.0091 (0.9761–1.0432)	0.5921
Venous thromboembolism	HannumAge	9	MR Egger	0.9802 (0.8627–1.1138)	0.7681
Venous thromboembolism	HannumAge	9	Weighted median	0.9935 (0.9529–1.0359)	0.7613
Venous thromboembolism	HannumAge	9	Weighted mode	0.9919 (0.9411–1.0454)	0.7687
Portal vein thrombosis	HannumAge	9	Inverse variance weighted	1.1249 (0.8908–1.4206)	0.3228
Portal vein thrombosis	HannumAge	9	MR Egger	1.0881 (0.4441–2.6656)	0.8588
Portal vein thrombosis	HannumAge	9	Weighted median	1.195 (0.8881–1.6078)	0.2394
Portal vein thrombosis	HannumAge	9	Weighted mode	1.1955 (0.8274–1.7274)	0.3695
Arterial embolism and thrombosis of lower extremity artery	PhenoAge	11	Inverse variance weighted	1.028 (0.9004–1.1737)	0.6825
Arterial embolism and thrombosis of lower extremity artery	PhenoAge	11	MR Egger	0.8759 (0.5801–1.3226)	0.5442
Arterial embolism and thrombosis of lower extremity artery	PhenoAge	11	Weighted median	1.0494 (0.9135–1.2056)	0.4955
Arterial embolism and thrombosis of lower extremity artery	PhenoAge	11	Weighted mode	1.0395 (0.8489–1.2728)	0.7157
Pulmonary embolism	PhenoAge	11	Inverse variance weighted	1.0019 (0.9697–1.0352)	0.9093
Pulmonary embolism	PhenoAge	11	MR Egger	0.9907 (0.8919–1.1005)	0.8661
Pulmonary embolism	PhenoAge	11	Weighted median	0.9975 (0.9563–1.0404)	0.906
Pulmonary embolism	PhenoAge	11	Weighted mode	0.9934 (0.9314–1.0594)	0.8433
DVT of lower extremities	PhenoAge	11	Inverse variance weighted	1.0322 (0.993–1.0729)	0.1084
DVT of lower extremities	PhenoAge	11	MR Egger	0.9951 (0.8842–1.12)	0.9371
DVT of lower extremities	PhenoAge	11	Weighted median	1.0302 (0.9798–1.0832)	0.2454
DVT of lower extremities	PhenoAge	11	Weighted mode	1.0403 (0.9633–1.1234)	0.3377
Other arterial embolism and thrombosis	PhenoAge	11	Inverse variance weighted	1.0622 (0.9532–1.1837)	0.275
Other arterial embolism and thrombosis	PhenoAge	11	MR Egger	1.224 (0.8755–1.7112)	0.2674
Other arterial embolism and thrombosis	PhenoAge	11	Weighted median	1.0374 (0.8921–1.2063)	0.6338
Other arterial embolism and thrombosis	PhenoAge	11	Weighted mode	1.0045 (0.7643–1.3203)	0.9749
Phlebitis and thrombophlebitis	PhenoAge	11	Inverse variance weighted	0.9955 (0.9607–1.0316)	0.8055
Phlebitis and thrombophlebitis	PhenoAge	11	MR Egger	0.9504 (0.8523–1.0598)	0.3842
Phlebitis and thrombophlebitis	PhenoAge	11	Weighted median	0.9721 (0.9269–1.0195)	0.2439
Phlebitis and thrombophlebitis	PhenoAge	11	Weighted mode	0.9647 (0.8999–1.0343)	0.3356
Venous thromboembolism	PhenoAge	11	Inverse variance weighted	1.0106 (0.9886–1.0331)	0.3471
Venous thromboembolism	PhenoAge	11	MR Egger	0.9872 (0.9229–1.0559)	0.7162
Venous thromboembolism	PhenoAge	11	Weighted median	1.0224 (0.9915–1.0542)	0.1569
Venous thromboembolism	PhenoAge	11	Weighted mode	1.0276 (0.9783–1.0795)	0.3029
Portal vein thrombosis	PhenoAge	11	Inverse variance weighted	0.9804 (0.8018–1.1987)	0.847
Portal vein thrombosis	PhenoAge	11	MR Egger	0.8399 (0.4436–1.5903)	0.6052
Portal vein thrombosis	PhenoAge	11	Weighted median	1.044 (0.841–1.2961)	0.6962
Portal vein thrombosis	PhenoAge	11	Weighted mode	1.0397 (0.736–1.4687)	0.8296
Arterial embolism and thrombosis of lower extremity artery	Circulating plasma alpha-Klotho levels	5	Inverse variance weighted	1.1493 (0.8205–1.6099)	0.4182
Arterial embolism and thrombosis of lower extremity artery	Circulating plasma alpha-Klotho levels	5	MR Egger	1.1627 (0.4427–3.0536)	0.7796
Arterial embolism and thrombosis of lower extremity artery	Circulating plasma alpha-Klotho levels	5	Weighted median	1.1047 (0.826–1.4774)	0.502
Arterial embolism and thrombosis of lower extremity artery	Circulating plasma alpha-Klotho levels	5	Weighted mode	1.4465 (0.9881–2.1175)	0.1305
Pulmonary embolism	Circulating plasma alpha-Klotho levels	5	Inverse variance weighted	1.1426 (0.9671–1.35)	0.1173
Pulmonary embolism	Circulating plasma alpha-Klotho levels	5	MR Egger	1.4498 (0.9937–2.1153)	0.1496
Pulmonary embolism	Circulating plasma alpha-Klotho levels	5	Weighted median	1.0134 (0.9147–1.1228)	0.7988
Pulmonary embolism	Circulating plasma alpha-Klotho levels	5	Weighted mode	0.989 (0.8905–1.0983)	0.8457
DVT of lower extremities	Circulating plasma alpha-Klotho levels	5	Inverse variance weighted	1.2193 (0.8978–1.6558)	0.2042
DVT of lower extremities	Circulating plasma alpha-Klotho levels	5	MR Egger	2.0177 (1.0882–3.7414)	0.1122
DVT of lower extremities	Circulating plasma alpha-Klotho levels	5	Weighted median	0.9698 (0.8614–1.0919)	0.6123
DVT of lower extremities	Circulating plasma alpha-Klotho levels	5	Weighted mode	0.9295 (0.8266–1.0452)	0.2889
Other arterial embolism and thrombosis	Circulating plasma alpha-Klotho levels	5	Inverse variance weighted	0.9483 (0.7654–1.1747)	0.6269
Other arterial embolism and thrombosis	Circulating plasma alpha-Klotho levels	5	MR Egger	0.9469 (0.5546–1.6166)	0.8543
Other arterial embolism and thrombosis	Circulating plasma alpha-Klotho levels	5	Weighted median	0.9694 (0.7551–1.2447)	0.8076
Other arterial embolism and thrombosis	Circulating plasma alpha-Klotho levels	5	Weighted mode	0.9778 (0.7295–1.3107)	0.888
Phlebitis and thrombophlebitis	Circulating plasma alpha-Klotho levels	5	Inverse variance weighted	1.1942 (0.9454–1.5084)	0.1366
Phlebitis and thrombophlebitis	Circulating plasma alpha-Klotho levels	5	MR Egger	1.8421 (1.2316–2.7552)	0.0589
Phlebitis and thrombophlebitis	Circulating plasma alpha-Klotho levels	5	Weighted median	1.0595 (0.9397–1.1945)	0.3451
Phlebitis and thrombophlebitis	Circulating plasma alpha-Klotho levels	5	Weighted mode	0.9812 (0.8428–1.1424)	0.8192
Venous thromboembolism	Circulating plasma alpha-Klotho levels	5	Inverse variance weighted	1.1657 (0.9512–1.4286)	0.1394
Venous thromboembolism	Circulating plasma alpha-Klotho levels	5	MR Egger	1.6063 (1.0464–2.4657)	0.1187
Venous thromboembolism	Circulating plasma alpha-Klotho levels	5	Weighted median	0.9973 (0.9304–1.069)	0.9387
Venous thromboembolism	Circulating plasma alpha-Klotho levels	5	Weighted mode	0.9914 (0.9258–1.0615)	0.8157
Portal vein thrombosis	Circulating plasma alpha-Klotho levels	5	Inverse variance weighted	0.8749 (0.6344–1.2067)	0.4154
Portal vein thrombosis	Circulating plasma alpha-Klotho levels	5	MR Egger	1.1939 (0.5134–2.7766)	0.7083
Portal vein thrombosis	Circulating plasma alpha-Klotho levels	5	Weighted median	0.8835 (0.5773–1.3521)	0.5684
Portal vein thrombosis	Circulating plasma alpha-Klotho levels	5	Weighted mode	1.2336 (0.6922–2.1987)	0.5157
Arterial embolism and thrombosis of lower extremity artery	GrimAge	4	Inverse variance weighted	1.1536 (0.8906–1.4943)	0.279
Arterial embolism and thrombosis of lower extremity artery	GrimAge	4	MR Egger	18.0742 (0.3639–897.6039)	0.2835
Arterial embolism and thrombosis of lower extremity artery	GrimAge	4	Weighted median	1.1728 (0.8793–1.5643)	0.2781
Arterial embolism and thrombosis of lower extremity artery	GrimAge	4	Weighted mode	1.2058 (0.7908–1.8387)	0.4485
Pulmonary embolism	GrimAge	4	Inverse variance weighted	0.9538 (0.8834–1.0298)	0.2266
Pulmonary embolism	GrimAge	4	MR Egger	1.2556 (0.3435–4.5889)	0.7635
Pulmonary embolism	GrimAge	4	Weighted median	0.958 (0.8783–1.045)	0.3337
Pulmonary embolism	GrimAge	4	Weighted mode	0.9639 (0.8607–1.0794)	0.5695
DVT of lower extremities	GrimAge	4	Inverse variance weighted	1.0336 (0.9102–1.1737)	0.6107
DVT of lower extremities	GrimAge	4	MR Egger	0.8912 (0.0646–12.2899)	0.9392
DVT of lower extremities	GrimAge	4	Weighted median	0.9879 (0.8777–1.1121)	0.8408
DVT of lower extremities	GrimAge	4	Weighted mode	0.9631 (0.8321–1.1146)	0.6485
Other arterial embolism and thrombosis	GrimAge	4	Inverse variance weighted	0.9157 (0.7085–1.1834)	0.5007
Other arterial embolism and thrombosis	GrimAge	4	MR Egger	0.6469 (0.0084–49.5764)	0.8622
Other arterial embolism and thrombosis	GrimAge	4	Weighted median	0.9018 (0.6714–1.2113)	0.4924
Other arterial embolism and thrombosis	GrimAge	4	Weighted mode	0.8513 (0.5649–1.2829)	0.4978
Phlebitis and thrombophlebitis	GrimAge	4	Inverse variance weighted	0.9427 (0.8385–1.0598)	0.3229
Phlebitis and thrombophlebitis	GrimAge	4	MR Egger	0.3423 (0.0475–2.4668)	0.3988
Phlebitis and thrombophlebitis	GrimAge	4	Weighted median	0.9756 (0.8756–1.087)	0.6545
Phlebitis and thrombophlebitis	GrimAge	4	Weighted mode	1.0024 (0.8523–1.1789)	0.979
Venous thromboembolism	GrimAge	4	Inverse variance weighted	0.9769 (0.919–1.0385)	0.4545
Venous thromboembolism	GrimAge	4	MR Egger	1.1206 (0.3206–3.917)	0.8749
Venous thromboembolism	GrimAge	4	Weighted median	0.9681 (0.9045–1.0362)	0.3501
Venous thromboembolism	GrimAge	4	Weighted mode	0.9634 (0.879–1.0559)	0.4835
Portal vein thrombosis	GrimAge	4	Inverse variance weighted	0.9253 (0.5139–1.6661)	0.7958
Portal vein thrombosis	GrimAge	4	MR Egger	235.0712 (0.0188–2,932,589.7984)	0.3742
Portal vein thrombosis	GrimAge	4	Weighted median	1.1034 (0.683–1.7828)	0.6876
Portal vein thrombosis	GrimAge	4	Weighted mode	1.1461 (0.6524–2.0134)	0.6675
Arterial embolism and thrombosis of lower extremity artery	IEAA	24	Inverse variance weighted	1.0144 (0.9426–1.0916)	0.7027
Arterial embolism and thrombosis of lower extremity artery	IEAA	24	MR Egger	1.0593 (0.8883–1.2632)	0.5278
Arterial embolism and thrombosis of lower extremity artery	IEAA	24	Weighted median	0.98 (0.8722–1.1012)	0.7344
Arterial embolism and thrombosis of lower extremity artery	IEAA	24	Weighted mode	0.978 (0.8353–1.1452)	0.7851
Pulmonary embolism	IEAA	24	Inverse variance weighted	0.9759 (0.9488–1.0038)	0.0902
Pulmonary embolism	IEAA	24	MR Egger	0.9579 (0.8952–1.0249)	0.2253
Pulmonary embolism	IEAA	24	Weighted median	0.9682 (0.9336–1.004)	0.081
Pulmonary embolism	IEAA	24	Weighted mode	0.9701 (0.9249–1.0175)	0.2245
DVT of lower extremities	IEAA	24	Inverse variance weighted	0.963 (0.9344–0.9924)	0.0141
DVT of lower extremities	IEAA	24	MR Egger	0.9668 (0.9005–1.0379)	0.3609
DVT of lower extremities	IEAA	24	Weighted median	0.9722 (0.9304–1.016)	0.2102
DVT of lower extremities	IEAA	24	Weighted mode	0.9647 (0.9115–1.0211)	0.2277
Other arterial embolism and thrombosis	IEAA	24	Inverse variance weighted	0.9885 (0.9048–1.0801)	0.7985
Other arterial embolism and thrombosis	IEAA	24	MR Egger	1.0082 (0.8149–1.2473)	0.9409
Other arterial embolism and thrombosis	IEAA	24	Weighted median	1.0294 (0.9161–1.1567)	0.6264
Other arterial embolism and thrombosis	IEAA	24	Weighted mode	1.0266 (0.8882–1.1866)	0.7257
Phlebitis and thrombophlebitis	IEAA	24	Inverse variance weighted	1.0061 (0.9694–1.0441)	0.7489
Phlebitis and thrombophlebitis	IEAA	24	MR Egger	1.0136 (0.9265–1.1088)	0.7715
Phlebitis and thrombophlebitis	IEAA	24	Weighted median	0.9871 (0.9453–1.0308)	0.5581
Phlebitis and thrombophlebitis	IEAA	24	Weighted mode	0.9821 (0.9132–1.0561)	0.6305
Venous thromboembolism	IEAA	24	Inverse variance weighted	0.9865 (0.966–1.0074)	0.2029
Venous thromboembolism	IEAA	24	MR Egger	0.9772 (0.9291–1.0278)	0.3812
Venous thromboembolism	IEAA	24	Weighted median	0.991 (0.9659–1.0169)	0.4925
Venous thromboembolism	IEAA	24	Weighted mode	0.986 (0.9538–1.0193)	0.4143
Portal vein thrombosis	IEAA	24	Inverse variance weighted	1.0204 (0.9042–1.1515)	0.743
Portal vein thrombosis	IEAA	24	MR Egger	0.9233 (0.6929–1.2303)	0.5912
Portal vein thrombosis	IEAA	24	Weighted median	1.0723 (0.8951–1.2846)	0.449
Portal vein thrombosis	IEAA	24	Weighted mode	1.1051 (0.823–1.4839)	0.5128
Arterial embolism and thrombosis of lower extremity artery	Fibroblast growth factor 23 levels	8	Inverse variance weighted	1.6766 (1.0314–2.7255)	0.0371
Arterial embolism and thrombosis of lower extremity artery	Fibroblast growth factor 23 levels	8	MR Egger	1.1593 (0.1739–7.7295)	0.8836
Arterial embolism and thrombosis of lower extremity artery	Fibroblast growth factor 23 levels	8	Weighted median	1.8414 (1.0253–3.307)	0.041
Arterial embolism and thrombosis of lower extremity artery	Fibroblast growth factor 23 levels	8	Weighted mode	2.3152 (0.8674–6.1796)	0.1376
Pulmonary embolism	Fibroblast growth factor 23 levels	8	Inverse variance weighted	1.6756 (0.873–3.2162)	0.1208
Pulmonary embolism	Fibroblast growth factor 23 levels	8	MR Egger	0.9083 (0.0731–11.2882)	0.9428
Pulmonary embolism	Fibroblast growth factor 23 levels	8	Weighted median	1.1584 (0.9495–1.4131)	0.1472
Pulmonary embolism	Fibroblast growth factor 23 levels	8	Weighted mode	1.1087 (0.8718–1.4099)	0.4281
DVT of lower extremities	Fibroblast growth factor 23 levels	8	Inverse variance weighted	1.838 (0.6461–5.2292)	0.2538
DVT of lower extremities	Fibroblast growth factor 23 levels	8	MR Egger	0.9454 (0.0159–56.2531)	0.9794
DVT of lower extremities	Fibroblast growth factor 23 levels	8	Weighted median	1.051 (0.8374–1.319)	0.6679
DVT of lower extremities	Fibroblast growth factor 23 levels	8	Weighted mode	1.0404 (0.7963–1.3592)	0.7801
Other arterial embolism and thrombosis	Fibroblast growth factor 23 levels	8	Inverse variance weighted	1.661 (1.0515–2.6237)	0.0296
Other arterial embolism and thrombosis	Fibroblast growth factor 23 levels	8	MR Egger	1.5355 (0.2888–8.1645)	0.6329
Other arterial embolism and thrombosis	Fibroblast growth factor 23 levels	8	Weighted median	1.535 (0.8227–2.8641)	0.1781
Other arterial embolism and thrombosis	Fibroblast growth factor 23 levels	8	Weighted mode	1.0397 (0.3378–3.1997)	0.9478
Phlebitis and thrombophlebitis	Fibroblast growth factor 23 levels	8	Inverse variance weighted	1.6514 (0.6913–3.945)	0.2589
Phlebitis and thrombophlebitis	Fibroblast growth factor 23 levels	8	MR Egger	0.6945 (0.0241–19.9755)	0.8386
Phlebitis and thrombophlebitis	Fibroblast growth factor 23 levels	8	Weighted median	1.0437 (0.8467–1.2865)	0.6888
Phlebitis and thrombophlebitis	Fibroblast growth factor 23 levels	8	Weighted mode	1.0552 (0.8176–1.3619)	0.6919
Venous thromboembolism	Fibroblast growth factor 23 levels	8	Inverse variance weighted	1.6847 (0.7696–3.6879)	0.192
Venous thromboembolism	Fibroblast growth factor 23 levels	8	MR Egger	0.8861 (0.0423–18.5408)	0.9404
Venous thromboembolism	Fibroblast growth factor 23 levels	8	Weighted median	1.0404 (0.9027–1.1991)	0.5843
Venous thromboembolism	Fibroblast growth factor 23 levels	8	Weighted mode	1.0073 (0.8367–1.2128)	0.9406
Portal vein thrombosis	Fibroblast growth factor 23 levels	8	Inverse variance weighted	0.9412 (0.4792–1.8486)	0.8604
Portal vein thrombosis	Fibroblast growth factor 23 levels	8	MR Egger	2.6005 (0.2243–30.1527)	0.4736
Portal vein thrombosis	Fibroblast growth factor 23 levels	8	Weighted median	0.8242 (0.3372–2.0145)	0.6716
Portal vein thrombosis	Fibroblast growth factor 23 levels	8	Weighted mode	0.7664 (0.1948–3.0149)	0.7147
Arterial embolism and thrombosis of lower extremity artery	Granulocyte proportions	17	Inverse variance weighted	0.445 (6e-04–330.4622)	0.8103
Arterial embolism and thrombosis of lower extremity artery	Granulocyte proportions	17	MR Egger	20.56 (0–3,348,467,402.5206)	0.7583
Arterial embolism and thrombosis of lower extremity artery	Granulocyte proportions	17	Weighted median	0.0144 (0–30.5736)	0.2781
Arterial embolism and thrombosis of lower extremity artery	Granulocyte proportions	17	Weighted mode	5e-04 (0–13.3953)	0.1634
Pulmonary embolism	Granulocyte proportions	17	Inverse variance weighted	0.6016 (0.0992–3.6488)	0.5806
Pulmonary embolism	Granulocyte proportions	17	MR Egger	1.3205 (0.009–193.2275)	0.9144
Pulmonary embolism	Granulocyte proportions	17	Weighted median	0.6808 (0.0584–7.941)	0.759
Pulmonary embolism	Granulocyte proportions	17	Weighted mode	0.5273 (0.0114–24.402)	0.7478
DVT of lower extremities	Granulocyte proportions	17	Inverse variance weighted	1.2366 (0.124–12.3367)	0.8564
DVT of lower extremities	Granulocyte proportions	17	MR Egger	0.3527 (5e-04–243.765)	0.759
DVT of lower extremities	Granulocyte proportions	17	Weighted median	4.0782 (0.1457–114.1372)	0.4083
DVT of lower extremities	Granulocyte proportions	17	Weighted mode	18.1044 (0.0116–28,202.9539)	0.4513
Other arterial embolism and thrombosis	Granulocyte proportions	17	Inverse variance weighted	0.0084 (0–14.3396)	0.2083
Other arterial embolism and thrombosis	Granulocyte proportions	17	MR Egger	6404.8057 (0–2,728,161,929,173.31)	0.4009
Other arterial embolism and thrombosis	Granulocyte proportions	17	Weighted median	0.8313 (1e-04–6261.454)	0.9676
Other arterial embolism and thrombosis	Granulocyte proportions	17	Weighted mode	0.6123 (0–94,765.3308)	0.9369
Phlebitis and thrombophlebitis	Granulocyte proportions	17	Inverse variance weighted	0.4733 (0.0462–4.8464)	0.5285
Phlebitis and thrombophlebitis	Granulocyte proportions	17	MR Egger	79.5555 (0.1914–33,072.3351)	0.1753
Phlebitis and thrombophlebitis	Granulocyte proportions	17	Weighted median	0.2253 (0.0144–3.5196)	0.2879
Phlebitis and thrombophlebitis	Granulocyte proportions	17	Weighted mode	0.2386 (0.0047–12.0739)	0.4845
Venous thromboembolism	Granulocyte proportions	17	Inverse variance weighted	0.6193 (0.1459–2.628)	0.5158
Venous thromboembolism	Granulocyte proportions	17	MR Egger	1.6196 (0.027–97.3142)	0.8206
Venous thromboembolism	Granulocyte proportions	17	Weighted median	0.987 (0.1371–7.1068)	0.9897
Venous thromboembolism	Granulocyte proportions	17	Weighted mode	3.4619 (0.0538–222.7793)	0.5671
Portal vein thrombosis	Granulocyte proportions	17	Inverse variance weighted	0.9453 (0–189,361.1019)	0.9928
Portal vein thrombosis	Granulocyte proportions	17	MR Egger	144,137,284.7907 (0–4.55585213355333e + 22)	0.2875
Portal vein thrombosis	Granulocyte proportions	17	Weighted median	1.8643 (0–4,086,034.95)	0.9334
Portal vein thrombosis	Granulocyte proportions	17	Weighted mode	16.8321 (0–67,786,189,361,647,096)	0.8795
Arterial embolism and thrombosis of lower extremity artery	Telomere length	130	Inverse variance weighted	1.155 (0.795–1.6781)	0.4496
Arterial embolism and thrombosis of lower extremity artery	Telomere length	130	MR Egger	0.9434 (0.4874–1.8261)	0.8631
Arterial embolism and thrombosis of lower extremity artery	Telomere length	130	Weighted median	1.1652 (0.6754–2.0102)	0.5827
Arterial embolism and thrombosis of lower extremity artery	Telomere length	130	Weighted mode	1.1461 (0.6302–2.0844)	0.6558
Pulmonary embolism	Telomere length	130	Inverse variance weighted	0.924 (0.8055–1.06)	0.2592
Pulmonary embolism	Telomere length	130	MR Egger	0.9166 (0.7188–1.1688)	0.4837
Pulmonary embolism	Telomere length	130	Weighted median	1.0155 (0.8218–1.255)	0.8864
Pulmonary embolism	Telomere length	130	Weighted mode	1.0736 (0.8581–1.3432)	0.5354
DVT of lower extremities	Telomere length	130	Inverse variance weighted	0.9092 (0.7871–1.0501)	0.1953
DVT of lower extremities	Telomere length	130	MR Egger	0.8291 (0.6428–1.0694)	0.1514
DVT of lower extremities	Telomere length	130	Weighted median	0.9131 (0.7318–1.1394)	0.4211
DVT of lower extremities	Telomere length	130	Weighted mode	0.8892 (0.6934–1.1403)	0.3565
Other arterial embolism and thrombosis	Telomere length	130	Inverse variance weighted	0.948 (0.6324–1.4211)	0.7959
Other arterial embolism and thrombosis	Telomere length	130	MR Egger	0.8661 (0.4229–1.7736)	0.6948
Other arterial embolism and thrombosis	Telomere length	130	Weighted median	0.9232 (0.4879–1.7466)	0.8058
Other arterial embolism and thrombosis	Telomere length	130	Weighted mode	0.8868 (0.4321–1.8201)	0.7438
Phlebitis and thrombophlebitis	Telomere length	130	Inverse variance weighted	1.1297 (0.9856–1.2949)	0.0798
Phlebitis and thrombophlebitis	Telomere length	130	MR Egger	1.0097 (0.794–1.2839)	0.9376
Phlebitis and thrombophlebitis	Telomere length	130	Weighted median	1.1047 (0.8867–1.3763)	0.3746
Phlebitis and thrombophlebitis	Telomere length	130	Weighted mode	1.0662 (0.8058–1.4107)	0.6546
Venous thromboembolism	Telomere length	130	Inverse variance weighted	0.9487 (0.8523–1.0561)	0.3359
Venous thromboembolism	Telomere length	130	MR Egger	0.9388 (0.7766–1.1349)	0.5155
Venous thromboembolism	Telomere length	130	Weighted median	0.8973 (0.7847–1.0261)	0.1134
Venous thromboembolism	Telomere length	130	Weighted mode	0.8787 (0.74–1.0433)	0.1423
Portal vein thrombosis	Telomere length	130	Inverse variance weighted	1.279 (0.7408–2.2082)	0.3771
Portal vein thrombosis	Telomere length	130	MR Egger	1.4762 (0.5635–3.8674)	0.4294
Portal vein thrombosis	Telomere length	130	Weighted median	1.2242 (0.5061–2.961)	0.6535
Portal vein thrombosis	Telomere length	130	Weighted mode	0.9886 (0.3491–2.7995)	0.9828

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