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Fig. 6 | Clinical Epigenetics

Fig. 6

From: DNA hypermethylation of PLTP mediated by DNMT3B aggravates vascular dysfunction in diabetic retinopathy via the AKT/GSK3β signaling pathway

Fig. 6

The anti-angiogenic properties of PLTP depend on PI3K/AKT/GSK3β pathway. Western blot analysis A and quantitative analysis of p-GSK3β/GSK3β B in HRMECs (HG + OE-PLTP vs HG + OE-PLTP + BRD3731, n = 3). Migration assay of HRMECs C and quantitative analysis D (HG, HG + OE-PLTP and HG + OE-PLTP + BRD3731, n = 5). Tube formation assay of HRMECs E, and quantitative analysis of nodes F and branches length G (HG, HG + OE-PLTP and HG + OE-PLTP + BRD3731, n = 3). HG, high glucose. *p < 0.05, **p < 0.01, ***p < 0.001

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Clinical Epigenetics

ISSN: 1868-7083

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