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Fig. 5 | Clinical Epigenetics

Fig. 5

From: DNA hypermethylation of PLTP mediated by DNMT3B aggravates vascular dysfunction in diabetic retinopathy via the AKT/GSK3β signaling pathway

Fig. 5

AKT/GSK3β is the Key Downstream Pathway of PLTP Gene. A KEGG enrichment analysis of differentially expressed genes after PLTP knockdown (NC vs siPLTP, n = 3). B Co-IP assays of PLTP interaction with AKT or GSK3β. Western blot analysis of PI3K/AKT/GSK3β C and quantitative analysis of p-AKT/AKT or p-GSK3β/GSK3β D in HRMECs (NC, NC + siPLTP, HG and HG + OE-PLTP, n = 3). Western blot analysis of PI3K/AKT/GSK3β E and quantitative analysis of p-AKT/AKT or p-GSK3β/GSK3β F in retina (NC vs DR mice, n = 3). KEGG, Kyoto Encyclopedia of Genes and Genomes; NC, normal control; HG, high glucose; DR, diabetic retinopathy. *p < 0.05, **p < 0.01, ***p < 0.001

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Clinical Epigenetics

ISSN: 1868-7083

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