Fig. 3

Cox proportional hazards regression analyses for the association between EAA and all-cause and cause-specific mortality. A AAHorvathAge, B AAHannumAge, C AAPhenoAge, D AAGrimAge, and E AAGrimAge2. Adjusted for age, sex, race, marital status, education level, PIR, BMI, smoking status, alcohol status, physical activity, diabetes, renal disease, ASCVD, CHF, COPD, cancer, total cholesterol, albumin and eGFR. ∗P value for trend. Effect sizes for per 5-year and per SD increase in EAA were also shown separately. EAA epigenetic age acceleration, PIR poverty income ratio, BMI body mass index, ASCVD atherosclerotic cardiovascular disease, CHF chronic heart failure, COPD chronic obstructive pulmonary disease, eGFR estimated glomerular filtration rate