Fig. 4
From: Regulation of nc886 (vtRNA2-1) RNAs is associated with cardiometabolic risk factors and diseases
The meta-analysis plots the association of predicted nc886 RNA levels with A diastolic blood pressure, B systolic bloop pressure in women, C HDL cholesterol and D type 2 diabetes. Individuals with elevated predicted nc886 RNA levels are compared to imprinted major allele homozygotes. A and B show diastolic and systolic BP to be significantly upregulated in the meta-analysis results, even though only one/two individual cohorts have a statistically significant association. Meanwhile, HDL, which is often regarded as the ‘good cholesterol’, is significantly downregulated in the meta-analysis shown in C, while type 2 diabetes is significantly upregulated, as shown in D, which is in line with our hypothesis that elevated nc886 RNA levels contribute to CMD dysregulation