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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Maternal uniparental disomy of chromosome 7: how chromosome 7-encoded imprinted genes contribute to the Silver–Russell phenotype

Fig. 3Fig. 3

Impact of upd(7)//7q)mat and the deletion in GRB10 on gene expression. a PCA plots of the full-length RNAseq data obtained from the GRB10DEL twins (blood), and the UPD7M/UPD7qM fibroblasts, and of differentially expressed genes (DEGs) compared to controls. b Heatmap visualization showing differential gene expression in the GRB10Del (left), and UPD7MAT/UPD7qMAT patients (right). Green indicates reduced expression, red indicates increased expression).c Differential gene expression analysis across the three different genetic constitutions, highlighting the number of genes that are either up- or downregulated. d Clustering analysis reveals distinct patterns of gene expression in GRB10DEL and UPD7MAT/UPD7qMAT, respectively

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Clinical Epigenetics

ISSN: 1868-7083

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