Low blood levels of selenium, selenoprotein P and GPx3 are associated with accelerated biological aging: results from the Berlin Aging Study II (BASE-II)

Table 4 Linear regression analysis of epigenetic age estimators on quartiles of GPx3 intensity (proteomics data) at baseline

Dependent Variable	Model		St. β	β	SE	p	lowCI	upCI	n
Horvath DNAmAA	1	Q2	− 0.033	− 0.322	0.462	0.487	− 1.228	0.585	689
		Q3	− 0.076	− 0.772	0.471	0.102	− 1.697	0.153
		Q4	− 0.064	− 0.628	0.458	0.171	− 1.527	0.272
	2	Q2	− 0.016	− 0.151	0.478	0.753	− 1.090	0.788	608
		Q3	− 0.048	− 0.475	0.489	0.332	− 1.436	0.486
		Q4	− 0.030	− 0.284	0.485	0.558	− 1.236	0.667
GrimAge DNAmAA	1	Q2	0.004	0.026	0.332	0.937	− 0.625	0.677	689
		Q3	− 0.059	− 0.430	0.338	0.203	− 1.094	0.233
		Q4	− 0.176	− 1.246	0.329	<0.001	− 1.892	− 0.601
	2	Q2	− 0.044	− 0.313	0.310	0.313	− 0.923	0.296	608
		Q3	− 0.085	− 0.628	0.318	0.048	− 1.252	− 0.005
		Q4	− 0.136	− 0.975	0.315	0.002	− 1.593	− 0.358
DunedinPACE	1	Q2	− 0.006	− 0.002	0.011	0.885	− 0.023	0.020	764
		Q3	− 0.044	− 0.011	0.011	0.309	− 0.033	0.010
		Q4	− 0.218	− 0.054	0.011	<0.001	− 0.076	− 0.033
	2	Q2	− 0.011	− 0.003	0.011	0.801	− 0.024	0.019	674
		Q3	− 0.039	− 0.010	0.011	0.369	− 0.032	0.012
		Q4	− 0.146	− 0.037	0.011	0.001	− 0.059	− 0.015

Model 1 is unadjusted. Model 2 is adjusted for chronological age, sex, BMI, smoking (packyears), and the first four genetic principal components (PC1 to PC4). The first quartile is used as reference group
St. = Standardized; SE = Standard Error; p = p value; lowCI = lower 95% confidence interval; upCI = upper 95% confidence interval

ISSN: 1868-7083