Low blood levels of selenium, selenoprotein P and GPx3 are associated with accelerated biological aging: results from the Berlin Aging Study II (BASE-II)

Table 3 Linear regression analysis of epigenetic age estimators on quartiles of SELENOP at baseline

Dependent Variable	Model		St. β	β	SE	p	lowCI	upCI	n
Horvath DNAmAA	1	Q2	0.033	0.310	0.435	0.477	− 0.545	1.164	765
		Q3	− 0.003	− 0.026	0.450	0.954	− 0.909	0.857
		Q4	0.012	0.120	0.451	0.791	− 0.766	1.005
	2	Q2	0.032	0.293	0.457	0.522	− 0.605	1.191	667
		Q3	0.026	0.252	0.467	0.590	− 0.666	1.169
		Q4	0.007	0.067	0.476	0.888	− 0.867	1.001
GrimAge DNAmAA	1	Q2	0.033	0.224	0.314	0.476	− 0.393	0.841	765
		Q3	− 0.071	− 0.514	0.325	0.114	− 1.152	0.124
		Q4	0.004	0.028	0.326	0.932	− 0.612	0.667
	2	Q2	0.032	0.220	0.298	0.460	− 0.365	0.806	667
		Q3	− 0.048	− 0.345	0.305	0.258	− 0.943	0.254
		Q4	0.002	0.015	0.310	0.962	− 0.595	0.624
DunedinPACE	1	Q2	− 0.076	− 0.018	0.010	0.078	− 0.039	0.002	848
		Q3	− 0.065	− 0.016	0.011	0.125	− 0.038	0.005
		Q4	− 0.096	− 0.024	0.011	0.024	− 0.045	− 0.003
	2	Q2	− 0.074	− 0.018	0.011	0.089	− 0.039	0.003	740
		Q3	− 0.067	− 0.017	0.011	0.119	− 0.038	0.004
		Q4	− 0.115	− 0.030	0.011	0.007	− 0.051	− 0.008

Model 1 is unadjusted. Model 2 is adjusted for chronological age, sex, BMI, smoking (packyears), and the first four genetic principal components (PC1 to PC4). The first quartile is used as reference
St. = Standardized; SE = Standard Error; p = p value; lowCI = lower 95% confidence interval; upCI = upper 95% confidence interval

ISSN: 1868-7083