Low blood levels of selenium, selenoprotein P and GPx3 are associated with accelerated biological aging: results from the Berlin Aging Study II (BASE-II)

Table 2 Linear regression analysis of epigenetic age estimators on selenium status (deficient vs. sufficient) at baseline

Dependent variable	Model	St. β	β	SE	p	lowCI	upCI	n
Horvath clock DNAmAA	1	0.021	0.175	0.306	0.566	− 0.425	0.775	782
Horvath clock DNAmAA	2	0.019	0.155	0.320	0.628	− 0.473	0.783	684
GrimAge DNAmAA	1	0.010	0.065	0.222	0.771	− 0.371	0.500	782
GrimAge DNAmAA	2	− 0.017	− 0.104	0.208	0.619	− 0.513	0.306	684
DunedinPACE	1	− 0.087	− 0.019	0.007	0.010	− 0.033	− 0.004	865
DunedinPACE	2	− 0.087	− 0.019	0.007	0.012	− 0.034	− 0.004	757

Model 1 is unadjusted. Model 2 is adjusted for chronological age, sex, BMI, smoking (packyears), and the first four genetic principal components (PC1 to PC4)
St. = Standardized; SE = Standard Error; p = p value; lowCI = lower 95% confidence interval; upCI = upper 95% confidence interval

ISSN: 1868-7083