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Table 2 Cross-sectional association between DNAm-based predictors and metabolic conditions

From: Cross-sectional and longitudinal association of seven DNAm-based predictors with metabolic syndrome and type 2 diabetes

DNAm-based predictor

MetS in F4 subsample

MetS in FF4 subsample

OR

95% CI

p

n

OR

95% CI

p

n

HorvathAA

1.03

1.01, 1.06

0.02

1719

1.00

0.98, 1.03

0.67

1864

HannumAA

1.01

0.99, 1.03

0.32

1719

1.00

0.98, 1.04

0.47

1864

GrimAA

1.09

1.06, 1.13

2.04E-08

1719

1.08

1.05, 1.12

4.80E-06

1864

PhenoAA

1.03

1.01, 1.04

4.67E-04

1719

1.04

1.02, 1.06

1.66E-04

1864

IEAA

1.03

1.00, 1.05

0.04

1719

1.00

0.98, 1.03

0.91

1864

EEAA

1.01

1.00, 1.03

0.13

1719

1.01

0.99, 1.04

0.13

1864

MRSa

1.22

1.07, 1.39

4.01E-03

1468

–

–

–

–

MRS (modified)a

1.27

1.12, 1.43

1.86E-04

1674

1.15

1.01, 1.31

0.03

1864

DNAm-based predictor

MetS score in F4 subsample

MetS score in FF4 subsample

OR

95% CI

p

n

OR

95% CI

p

n

HorvathAA

1.02

1.00, 1.04

0.07

1708

1.02

1.00, 1.04

0.13

1852

HannumAA

1.01

0.99, 1.02

0.26

1708

1.00

0.98, 1.03

0.64

1852

GrimAA

1.08

1.06, 1.11

6.87E-10

1708

1.09

1.06, 1.12

4.60E-10

1852

PhenoAA

1.03

1.02, 1.04

1.59E-06

1708

1.04

1.02, 1.05

3.64E-06

1852

IEAA

1.01

0.99, 1.04

0.17

1708

1.01

0.99, 1.03

0.22

1852

EEAA

1.01

1.00, 1.03

0.06

1708

1.01

0.99, 1.03

0.23

1852

MRSa

1.17

1.05, 1.31

5.45E-03

1458

–

–

–

–

MRS (modified)a

1.22

1.10, 1.35

1.68E-04

1663

1.15

1.04, 1.27

6.65E-03

1852

DNAm-based predictor

T2D in F4 subsample

T2D in FF4 subsample

OR

95% CI

p

n

OR

95% CI

p

n

HorvathAA

1.03

0.99, 1.07

0.10

1709

1.00

0.97, 1.05

0.54

1866

HannumAA

1.03

1.00, 1.06

0.02

1709

1.00

0.96, 1.04

0.24

1866

GrimAA

1.09

1.04, 1.13

1.38E-04

1709

1.09

1.04, 1.14

2.66E-04

1866

PhenoAA

1.04

1.01, 1.06

9.82E-04

1709

1.03

1.00, 1.06

0.01

1866

IEAA

1.03

0.99, 1.07

0.13

1709

1.00

0.96, 1.04

0.97

1866

EEAA

1.03

1.00, 1.05

0.02

1709

1.01

0.98, 1.05

0.49

1866

MRSa

1.41

1.16, 1.71

4.47E-04

1458

–

–

–

–

MRS (modified)a

1.41

1.18, 1.68

1.15E-04

1664

1.27

1.06, 1.53

9.83E-03

1866

  1. Odd Ratios were generated using logistic regression, except for MetS Score using ordinal regression. Models were fully adjusted for chronological age, sex, physical activity level, smoking status, body mass index (only for T2D), alcohol consumption and technical covariates. Regressions of each metabolic condition were based on N ≤ 1722 and N ≤ 1872 observations in F4 and FF4 subsample respectively, with varying number of observations due to missing values (column “n” indicates the number of observations included in each regression under complete case analysis)
  2. MetS, metabolic syndrome; OR, odd ratio; CI, confidence interval; AA, age acceleration; IEAA, intrinsic epigenetic age acceleration; EEAA, extrinsic epigenetic age acceleration; MRS, mortality risk score; T2D, type 2 diabetes
  3. Shown in bold are statistically significant associations (p < 0.05)
  4. aThe coefficients of MRS & MRS (modified) were standardized to its standard deviation
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Clinical Epigenetics

ISSN: 1868-7083

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