Fig. 1

Association of DNAm-based predictors with time-to-incident T2D. Scatter plot showing the effect estimates generated using Cox proportional hazards model under the crude and fully adjusted models. The former adjusted for age, sex and technical covariates, the latter included additionally body mass index, physical activity, smoking status, and alcohol consumption. Abbreviations: T2D, type 2 diabetes; MRS, mortality risk score; AA, age acceleration; EEAA, extrinsic epigenetic age acceleration; IEAA, intrinsic epigenetic age acceleration. *Effect estimate standardized to one standard deviation of the DNAm-based predictor