Skip to main content

Table 2 Novel CpG sites identified in the population-combined and population-specific meta-analysisa

From: Methylome-wide association analyses of lipids and modifying effects of behavioral factors in diverse race and ethnicity participants

Marker

Chr:pos

Trait

Gene

Population-combined

meta-analysis

(N = 9,561)

Meta-analysis in White participants

(N = 3,764)

Meta-analysis in African American participants

(N = 4,912)

Meta-analysis in Hispanic/Latino participants

(N = 712)

Beta (SE)

P

Beta (SE)

P

Beta (SE)

P

Beta (SE)

P

Novel CpG sites identified in the population-combined meta-analysis

cg17438457

1:53,094,893

HDL

–

 −3.02 (0.43)

2.13E-12

 −3.35 (0.68)

4.42E-7

 −2.19 (0.71)

2.13E-3

 −3.56 (1.50)

1.75E-2

cg00522451

2:113,464,048

HDL

–

1.68 (0.30)

2.29E-8

1.81 (0.55)

5.83E-4

1.75 (0.41)

1.99E-5

0.31 (1.12)

7.79E-1

cg18194850

3:67,699,305

HDL

SUCLG2

 −1.60 (0.26)

1.10E-9

 −2.22 (0.46)

9.00E-7

 −1.19 (0.37)

1.28E-3

 −1.08 (1.03)

2.95E-1

cg01671681

3:155,421,735

HDL

PLCH1

1.43 (0.24)

2.19E-9

1.50 (0.38)

4.26E-5

1.25 (0.37)

6.28E-4

2.77 (0.97)

4.26E-3

cg02387843

4:9,892,887

HDL

SLC2A9

2.10 (0.30)

4.54E-12

1.73 (0.51)

3.48E-4

2.39 (0.45)

8.80E-8

2.25 (1.19)

5.85E-2

cg16905822

10:924,646

HDL

LARP4B

 −2.24 (0.40)

2.40E-8

 −2.28 (0.65)

3.47E-4

 −2.38 (0.61)

9.57E-5

 −0.81 (1.52)

5.97E-1

cg23669118

16:1,538,347

HDL

C16orf38

 −1.76 (0.29)

1.37E-9

 −1.71 (0.50)

5.49E-4

 −1.67 (0.41)

5.20E-5

 −2.57 (1.14)

2.34E-2

cg24403644

20:42,574,624

HDL

TOX2

 −2.55 (0.43)

3.30E-9

 −2.32 (0.72)

1.09E-3

 −2.91 (0.63)

4.50E-6

 −1.04 (1.57)

5.07E-1

cg03607951

1:79,085,586

LDL

IFI44L

0.76 (0.12)

3.47E-10

0.75 (0.23)

1.14E-3

0.78 (0.16)

8.16E-7

0.13 (0.63)

8.34E-1

cg02387843

4:9,892,887

TG

SLC2A9

 −1.83 (0.32)

1.24E-8

 −1.45 (0.43)

7.79E-4

 −2.07 (0.41)

5.01E-7

 −2.25 (1.25)

7.20E-2

cg00960906

5:31,769,846

TG

-

 −1.63 (0.30)

7.87E-8

 −2.35 (0.44)

7.48E-8

 −1.02 (0.37)

5.87E-3

 −1.44 (1.19)

2.25E-1

cg07398791

5:118,676,053

TG

TNFAIP8

 −1.81 (0.28)

1.13E-10

 −1.67 (0.37)

8.26E-6

 −2.07 (0.36)

1.05E-8

0.09 (1.04)

9.28E-1

cg18722504

5:139,712,966

TG

HBEGF

 −2.39 (0.43)

2.97E-8

 −2.97 (0.59)

4.11E-7

 −1.70 (0.55)

2.02E-3

 −3.40 (1.64)

3.85E-2

cg14761417

7:130,636,860

TG

FLJ43663

 −2.38 (0.33)

1.40E-12

 −2.13 (0.47)

7.25E-6

 −2.20 (0.41)

1.06E-7

 −5.06 (1.30)

9.79E-5

cg04927537

17:76,976,091

TG

LGALS3BP

1.11 (0.18)

2.42E-9

1.22 (0.28)

1.53E-5

1.11 (0.22)

2.53E-7

 −0.18 (0.73)

8.01E-1

cg24673765

19:36,247,869

TG

HSPB6

1.89 (0.35)

1.07E-7

1.47 (0.53)

5.64E-3

2.11 (0.42)

4.13E-7

1.30 (1.40)

3.55E-1

cg24403644

20:42,574,624

TG

TOX2

2.84 (0.46)

4.87E-10

2.10 (0.62)

6.81E-4

3.43 (0.59)

5.05E-9

2.83 (1.65)

8.62E-2

cg04945608

20:43,118,723

TG

TTPAL

 −2.34 (0.36)

1.10E-10

 −2.21 (0.52)

2.03E-5

 −2.22 (0.44)

4.46E-7

 −3.65 (1.44)

1.11E-2

Novel CpG site identified in the EA-specific meta-analysis

 

cg03584506

11: 39,689,828

TG

-

 −0.99 (0.22)

4.29E-6

 −1.94 (0.36)

4.66E-8

 −0.55 (0.24)

2.24E-2

 −1.05 (0.90)

2.44E-1

  1. HDL, high-density lipoprotein; LDL, low-density lipoprotein; TC, total cholesterol; TG, triglycerides
  2. aAssociation results presented in this table are derived from the discovery stage. Detailed results in the replication stage are presented in Supplemental Table 4–6