The effect of 1,25(OH)2D3 on Dickkopf-1 methylation in colorectal cancer

Clinical Epigenetics

Table 1 Associations of serum DKK1 level with clinicopathological characteristics of CRC patients

Variable	No. of cases	Serum DKK1		p values
Variable	No. of cases	Low (≤ 11.81 ng/ml)	High (> 11.81 ng/ml)	p values
Age(year)				0.359
< 60	28	14	14
≥ 60	29	18	11
Gender				0.907
Male	36	20	16
Female	21	12	9
BMI				0.790
18.5–23.9	40	22	18
> 23.9	17	10	7
Tumour size (cm)				0.249
≥ 5	27	13	14
< 5	30	19	11
Tumour location				0.962
Colon	34	19	15
Rectum	23	13	10
Histology differentiation			0.847
Well and moderate	35	20	15
Poor	22	12	10
Depth of invasion				0.409
T1–T2	13	6	7
T3–T4	44	26	18
Lymph node metastasis			0.554
Yes	23	14	9
No	34	18	16
Venous permeation			0.366
Yes	22	14	8
No	35	18	17
Perineural invasion				0.017*
Yes	16	13	3
No	41	19	22
MMR				0.227
Deficient	18	8	10
Competent	39	24	15
25(OH) D				0.048*
Deficient	32	22	10
Insufficient	14	5	9
Sufficient	11	4	7

ISSN: 1868-7083