Table 4 Linear regression analysis of metabolic factors and log2 adjusted reproductive hormones and sperm parameters in whole study population (n = 38 for sperm parameters, n = 40 for hormones, and n = 23 for change in HbA1c)
From: Type 2 diabetes impacts DNA methylation in human sperm
| Â | Raw | Age-Adjusted | ||||||
|---|---|---|---|---|---|---|---|---|
HbA1c | Change in HbA1c | Fructosamine | BMI | HbA1c | Change in A1c | Fructosamine | BMI | |
FSH (mIU/mL) | 0.21 (0.03) | 0.48 (0.11) | 0.001 (0.41) | 0.01 (0.81) | 0.11 (0.24) | 0.54 (0.06) | 0.0004 (0.79) | − 0.004 (0.86) |
LH (mIU/ml) | 0.08 (0.29) | − 0.03 (0.91) | − 0.0003 (0.86) | 0.03 (0.14) | 0.08 (0.37) | − 0.001 (0.99) | − 0.0004 (0.78) | 0.03 (0.16) |
Estradiol (pg/ml) | 0.08 (0.11) | − 0.04 (0.76) | 0.002 (0.07) | − 0.002 (0.89) | 0.08 (0.16) | − 0.01 (0.91) | 0.002 (0.09) | − 0.003 (0.80) |
Total Testosterone (ng/dL) | − 0.10 (0.15) | 0.19 (0.17) | 0.001 (0.50) | − 0.05 (0.001) | − 0.10 (0.21) | 0.18 (0.19) | 0.001 (0.42) | − 0.05 (0.002) |
SHBG (nmol/mL) a | 0.52 (0.70) | − 0.29 (0.92) | 0.03 (0.30) | − 0.78 (0.01) | − 1.02 (0.44) | 0.64 (0.81) | 0.01 (0.56) | − 0.92 (< 0.01) |
Ejaculate Volume (mL) | − 0.17 (0.21) | − 0.07 (0.76) | − 0.003 (0.24) | − 0.01 (0.74) | − 0.10 (0.47) | − 0.14 (0.50) | − 0.002 (0.38) | − 0.001 (0.97) |
Sperm Concentration (M/mL) | 0.07 (0.67) | − 0.14 (0.60) | 0.003 (0.22) | − 0.11 (0.001) | 0.14 (0.42) | − 0.16 (0.55) | 0.004 (0.15) | − 0.105 (0.001) |
Total Sperm Count (mil/ejaculate) | − 0.11 (0.63) | − 0.21 (0.53) | 0.001 (0.90) | − 0.117 (0.01) | 0.03 (0.90) | − 0.30 (0.34) | 0.002 (0.63) | − 0.105 (0.02) |
Total Motility (%) a | − 3.3 (0.30) | − 2.7 (0.65) | 0.01 (0.91) | − 1.7 (0.01) | − 0.38 (0.90) | − 4.6 (0.41) | 0.04 (0.47) | − 1.5 (0.01) |
Total Progressive Motility (%) a | − 1.7 (0.25) | − 3.7 (0.19) | − 0.01 (0.74) | − 0.67 (0.03) | − 0.41 (0.78) | − 4.4 (0.11) | 0.004 (0.86) | − 0.54 (0.06) |
Total Motile Sperm Number (M) a | − 6.85 (0.40) | − 15.8 (0.38) | 0.09 (0.53) | − 2.94 (0.09) | − 2.39 (0.78) | − 19.3 (0.28) | 0.14 (0.32) | − 2.50 (0.14) |
Adiponectin (ug/mL) | − 0.15 (0.07) | − 0.18 (0.27) | 0.001 (0.37) | − 0.002 (0.93) | − 0.18 (0.04) | − 0.18 (0.28) | 0.001 (0.40) | − 0.002 (0.89) |
HDL (mg/dL) | − 0.17 (0.01) | 0.14 (0.16) | − 0.0001 (0.88) | − 0.01 (0.61) | − 0.14 (0.01) | 0.14 (0.19) | − 0.0001 (0.88) | − 0.01 (0.61) |
HbA1c (%) a | – | − 0.87 (0.011) | 0.009 (0.002) | 0.03 (0.39) | – | − 0.80 (0.02) | 0.01 (0.004) | 0.02 (0.58) |