Table 2 The expression of CBXs in different tumours and its effect on OS reduction

CBX1

BC,CRC,EC,GC,HCC,HNSCC

LUAD,NSCLC,OC,PAAD,Sarcoma

ccRCC,OC

(H):LUAD,GC,HCC,OC,Sarcoma

(L):ccRCC

[33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51]

CBX2

AML,BC,CRC,EC,GC,Glioma,HCCHNSCC,LUAD,NSCLC,OC,SKCM

NONE

(H):BC,HCC,OC

(L):PAAD

[33,34,35, 35,36,37, 39,40,41,42,43, 35, 35, 36, 51,52,53,54,55,56,57,58,59,60,61,62,63,64,65]

CBX3

BC,ccRCC,CRC,EC,ESCC,GC

Glioma,HCC,HNSCC,LUAD

NSCLC,OC,OS,Osteosarcoma,PAADPC,PCa,Sarcoma,SKCM,TSCC

UBC

NONE

(H):BC,CRC,EC,GC,Glioma,HCC,HNSCC,OC,Osteosarcoma,Sarcoma

(L):GC

[14, 33,34,35, 67, 33, 40,41,42,43,44, 46,47,48, 69, 70, 53,54,55, 43, 62, 44, 46, 66,67,68,69,70, 75, 50, 51]

CBX4

BC,ccRCC,CRC,EC,GC

HCC,HNSCC,LUAD,NSCLC,OS

Osteosarcoma Sarcoma

KrasG12D-mutated LUAD

(H):BC,CRC,EC,GC,HCC,LUAD

(L):LUAD

[81, 76, 33, 39,40,41,42,43, 45,46,47,48, 40,41,42,43, 76,77,78,79,80,81]

CBX5

BC,CRC,EC,Glioma,GC,HCC

LUAD,NSCLC,PAAD,Sarcoma

SKCM

ccRCC,EGFR-mutated LUAD

(H):BC,CRC,GC,HCC,LUAD,Sarcoma,SKCM

(L):ccRCC,HNSCC

[33,34,35,36,37, 39,40,41,42,43,44,45,46,47,48, 45,46,47, 64, 48, 50]

CBX6

GC,HCC,HNSCC,Sarcoma,SKCM

BC,ccRCC,CRC,Glioma,GC,NSCLC,OC

(H):CRC,GC,HCC

(L):BC,ccRCC,Glioma,PAAD

[53, 54, 33, 34, 83, 60, 40, 62, 45, 46, 73, 74, 64, 48, 83,84,85]

CBX7

BC,GC,HCC

BC,CCA,ccRCC,CRC,EC,GC,Glioma,HNSCC,LUAD

NSCLC,OC,PAAD,PC,SKCM,UBC

(H):GC

(L):BC,CCA,ccRCC,EC,GC,Glioma,HCC,LUAD,PAAD,Sarcoma

[33,34,35,36, 38,39,40,41,42,43, 38, 69, 39, 40, 52,53,54, 62, 45, 62,63,64, 74, 63, 64, 86,87,88,89]

CBX8

BC,ccRCC,CEC,EC,ESCC,GC

Glioma,HCC,HNSCC,LSCC,LUADOC,PAAD,PC,Sarcoma,TSCC,UBC

SKCM

(H):BC,ccRCC,CRC,EC,GC,Glioma,HCC,YBC

(L):LUAD,PAAD

[33,34,35, 34, 59, 41,42,43,44,45,46,47,48, 43, 44, 91, 92, 45, 46, 93, 47, 74, 90,91,92,93,94,95]