Epigenetic regulatory protein chromobox family regulates multiple signalling pathways and mechanisms in cancer

Su, Weiyu; Wang, Weiwen; Zhang, Guanghui; Yang, Lianhe

doi:10.1186/s13148-025-01852-w

Clinical Epigenetics

Table 1 CBX proteins’s expression and signalling pathways in different tumours and their function

From: Epigenetic regulatory protein chromobox family regulates multiple signalling pathways and mechanisms in cancer

CBX	Signalling pathway	Tumour	Expression level	Function		Reference
CBX1	Wnt/β-catenin	HCC	H	Carcinogenic factor	Tumour cell proliferation, migration	[96]
CBX2	Wnt/β-catenin	GC	H	Carcinogenic factor	Tumour cell proliferation, migration, invasion	[97]
	Hippo	HCC	H	Carcinogenic factor	Tumour cell proliferation, apoptosis	[98]
	PI3K/AKT/mTOR	BC,GBM	H	Carcinogenic factor	Tumour cell proliferation ,migration, invasion	[99, 100]
	ERK/MAPK	AML	H	Carcinogenic factor	Tumour cell proliferation, migration, invasion	[10]
CBX3	Wnt/β-catenin	CRC	H	Carcinogenic factor	Tumour cell proliferation, cycle, apoptosis	[101]
	PI3K/AKT/mTOR	ccRCC,PCa	H	Carcinogenic factor	Tumour cell angiogenesis, immunological disorders, proliferation, migration, invasion	[102, 103]
	TGF-β	PC	H	Carcinogenic factor	Tumour cell proliferation,migration, invasion	[9]
	P53-P21-RB	ESCC,TSCC,CRC	H	Carcinogenic factor	Tumour cell proliferation, cycle	[104, 105]
	Rho-ROCK	LUAD	H	Carcinogenic factor	Tumour cell proliferation,migration, invasion	[106]
CBX4	Wnt/β-catenin	LUAD	H	Carcinogenic factor	Tumour cell proliferation, cycle	[107]
	Hippo	LUAD (KrasG12D mutations)	L	Carcinogenic factor	Tumour cell apoptosis	[81]
	NF-κB	NSCLC,OS	H	Carcinogenic factor	Tumour cell proliferation, migration, invasion	[108, 109]
	Notch	BC	H	Carcinogenic factor	Tumour cell proliferation, migration	[77]
	HIF-1α	HCC,OS	H	Carcinogenic factor	Tumour cell proliferation, apoptosis, migration, invasion, angiogenesis	[12, 110]
CBX5	E2F1/BIRC5	LUAD	L	Carcinogenic factor	Tumour cell proliferation, apoptosis, cycle, chemoresistance	[82]
CBX6	NF-κB	HCC BC	H L	Carcinogenic factor Tumour suppressor	Tumour cell proliferation,cycle, migration, invasion	[111, 112]
CBX7	Wnt/β-catenin	UBC,HCC,BC	L	Tumour suppressor	Tumour cell proliferation,cycle, migration, invasion	[5, 113, 114]
	Hippo	GBM	L	Tumour suppressor	Tumour cell proliferation, apoptosis, migration, invasion	[6]
	PI3K/AKT/mTOR	UBC	L	Tumour suppressor	Tumour cell proliferation, migration, invasion, chemoresistance	[115]
	NF-κB	ccRCC PC GC	L L H	Tumour suppressor Tumour suppressor Carcinogenic factor	Tumour cell proliferation, migration, chemoresistance, stem cell-like properties	[116, 117, 8]
	TGF-β	CCA	L	Tumour suppressor	Tumour cell proliferation, apoptosis, migration, invasion	[118]
	ERK/MAPK	UBC,NSCLC	L	Tumour suppressor	Tumour cell proliferation, cycle,migration, invasion, stem cell-like properties	[119, 120]
	P53-P21	Thyroid cancer,Lung cancer,Glioma	L	Tumour suppressor	Tumour cell proliferation, cycle, apoptosis ,migration, invasion	[121,122,123]
CBX8	Wnt/β-catenin	LSCC	H	Carcinogenic factor	Tumour cell proliferation, apoptosis, migration, invasion	[124]
	PI3K/AKT/mTOR	PC	H	Carcinogenic factor	Tumour cell proliferation	[7]
	ERK/MAPK	HCC	H	Carcinogenic factor	Tumour cell proliferation, migration, invasion, stem cell-like properties	[125]
	Notch	BC	H	Carcinogenic factor	Tumour cell proliferation, stem cell-like properties	[11]
	P53-P21	UBC,HCC	H	Carcinogenic factor	Tumour cell proliferation, cycle	[126, 127]
	Rho-ROCK	GBM,BC,Lung cancer	H	Carcinogenic factor	Tumour cell proliferation, migration, invasion	[128]
	PRDM1/c-FOS	UBC	H	Carcinogenic factor	Tumour cell proliferation, apoptosis,migration, invasion	[129]

Expression Level: High/Low (H/L)

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ISSN: 1868-7083

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