Table 4 Causal estimates of significant CpG loci for alcohol-related methylation on QT interval susceptibility by epigenetic Mendelian randomization
CpG | CpG.Chr | CpG.Pos | Nearest gene(s) | No.SNP | Method | Beta | SE | LCI | UCI | P value |
|---|---|---|---|---|---|---|---|---|---|---|
cg03345232 | 14 | 92,981,121 | RIN3 | 2 | IVW | − 0.44 | 0.11 | − 0.66 | − 0.21 | 1.22E-04 |
cg04605617 | 1 | 20,501,558 | PLA2G2C | 2 | IVW | 0.18 | 0.02 | 0.13 | 0.22 | 1.82E-13 |
cg07091481 | 10 | 82,169,149 | C10orf58 | 1 | Wald ratio | 1.04 | 0.52 | 0.02 | 2.06 | 0.046 |
cg07104958 | 10 | 46,168,551 | ANUBL1 | 1 | Wald ratio | − 0.77 | 0.24 | − 1.24 | − 0.30 | 0.001 |
cg07512517 | 7 | 38,408,106 | - | 1 | Wald ratio | 0.77 | 0.38 | 0.02 | 1.52 | 0.045 |
cg07567724 | 1 | 153,777,721 | GATAD2B | 1 | Wald ratio | 0.55 | 0.27 | 0.01 | 1.09 | 0.045 |
cg12807764 | 5 | 146,864,669 | - | 1 | Wald ratio | 0.75 | 0.31 | 0.14 | 1.36 | 0.017 |
cg20374917 | 11 | 128,603,874 | FLI1 | 1 | Wald ratio | -0.78 | 0.37 | -1.50 | -0.05 | 0.036 |