Dissecting the causal effects of smoking, alcohol consumption, and related DNA methylation markers on electrocardiographic indices

Table 3 Directional horizontal pleiotropy test

Exposure	Outcome	Method	Intercept value	Std. Error	F value	P value
AUD	PWD	MR-Egger intercept	0.14	1.19		0.926
	PWD	MR-RAPS			3.54	0.352
	PR interval	MR-Egger intercept	0.002	0.04		0.952
	PR interval	MR-RAPS			0.12	0.988
	QT interval	MR-Egger intercept	0.01	0.12		0.904
		MR-RAPS			2.36	0.456
		Radial Egger	0.36	0.93		0.715
		Radial Egger corrected	− 0.55	0.34		0.197
PAU	PWD	MR-Egger intercept	0.22	0.22		0.399
	PWD	MR-RAPS			14.96	0.191
	PR interval	MR-Egger intercept	0.01	0.04		0.727
	PR interval	MR-RAPS			0.41	0.861
	QT interval	MR-Egger intercept	− 0.08	0.06		0.191
	QT interval	MR-RAPS			1.10	0.396
DrnkWk	PWD	MR-Egger intercept	− 0.15	0.37		0.698
	PWD	MR-RAPS			2.24	0.133
	PR interval	MR-Egger intercept	0.006	0.03		0.831
	PR interval	MR-RAPS			1.48	0.178
	QT interval	MR-Egger intercept	− 0.031	0.03		0.315
		MR-RAPS			0.86	0.538
		Radial Egger	− 0.27	0.27		0.317
		Radial Egger corrected	− 0.22	0.21		0.303
CigDay	PWD	MR-Egger intercept	− 0.82	0.52		0.187
	PWD	MR-RAPS			0.78	0.693
	PR interval	MR-Egger intercept	− 0.005	0.03		0.891
	PR interval	MR-RAPS			1.09	0.384
	QT interval	MR-Egger intercept	0.09	0.07		0.171
	QT interval	MR-RAPS			0.21	0.969
SmkInit	PWD	MR-Egger intercept	− 0.15	0.20		0.459
	PWD	MR-RAPS			0.93	0.490
	PR interval	MR-Egger intercept	− 0.07	0.02		0.002
		MR-RAPS			2.83	0.046
		Radial Egger	− 1.71	0.44		1.41E-04
		Radial Egger corrected	− 0.92	0.37		0.014
	QT interval	MR-Egger intercept	0.03	0.05		0.573
		MR-RAPS			0.38	0.980
		Radial Egger	1.16	0.46		0.012
		Radial Egger corrected	1.17	0.34		0.001

PWD P-wave duration, AUD alcohol use disorders, PAU problematic alcohol use, DrnkWk drinks per week, SmkInit smoking initiation, CigDay cigarettes per day, MR-RAPS MR-Robust Adjusted Profile Score, radial Egger corrected represents outlier(s)-corrected analyses

ISSN: 1868-7083