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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Dissecting the causal effects of smoking, alcohol consumption, and related DNA methylation markers on electrocardiographic indices

Fig. 5

Epigenetic MR estimates and colocalization analysis. A Epigenetic causal estimates of significant CpG loci for alcohol-related methylation on QT interval susceptibility. B Genomic localization of DNA methylation site: CpG island cg04605617.cg04605617 localizes to chromosome 1 at position 20,501,558 and maps to the promoter region of the gene PLA2G2C. C Regional map of evidence for colocalization of methylated CpG sites with QT interval susceptibility. 99.7% posterior probability supports that rs12881206 is a shared causal variant for cg03345232 methylation and QT interval susceptibility. IVW, radial inverse variance weighted; mQTL, methylation quantitative trait loci

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Clinical Epigenetics

ISSN: 1868-7083

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