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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Mendelian randomization provides a multi-omics perspective on the regulation of genes involved in ribosome biogenesis in relation to cardiac structure and function

Fig. 3

Forest map of RNA splicing and SMR analysis results of cardiac structure–function. OR, odds ratio; CI, confidence interval; P-adj-SMR: The FDR-corrected p value in SMR analysis, where SMR analysis refers to summary data-based Mendelian randomization, utilizing summary-level data from GWAS and quantitative trait loci (QTL) studies to test for pleiotropic associations between gene expression levels and the complex traits of interest. FDR correction stands for false discovery rate correction, which is the expected proportion of falsely rejected (i.e., rejecting the true null hypothesis) null hypotheses among all the rejected null hypotheses. This correction is performed using the R programming language. Within the ERI1 gene, multiple independent linkage disequilibrium (LD) blocks harboring distinct top SNPs were identified in Thyroid and Lung tissues. Independent analyses of these SNPs yielded significant, albeit varying, results

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Clinical Epigenetics

ISSN: 1868-7083

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