Table 2 Significant DMPs associated with late severe GI and GU adverse effects

cg13574053

22

49,749,233

8.69E−09

–

–

cg00162348

16

30,773,695

3.03E−08

RNF40 and C16orf93

5’UTR; TSS200

cg08657377

7

139,875,178

4.90E−08

JHDM1D

Body

cg01353941

3

191,781,655

6.61E−08

–

–

cg18382341

1

230,778,080

7.16E−08

COG2

TSS00

cg18009484

11

131,630,593

1.15E−07

NTM

Body

cg25666010

1

1,726,516

1.92E−07

GNB1

Body

cg09057763

16

73,205,994

1.97E−07

–

–

cg27230044

7

94,285,993

2.94E−07

PEG10

TSS1500

cg14825555

1

27,190,639

3.58E−07

SFN

1stExon; 3’UTR

cg15490596

19

54,415,736

3.92E−07

CACNG7

TSS1500

cg02534744

19

863,226

4.13E−07

CFD

Body

cg17872757

11

128,564,180

4.23E−07

FLI1

Body; 5’UTR

cg05779526

3

23,084,046

4.34E−07

–

–

cg08417142

16

89,439,771

6.50E−07

ANKRD11

5’UTR

cg07268021

13

30,054,459

7.13E−07

MTUS2

Body

cg07345874

14

21,248,717

8.05E−07

RNASE6

TSS1500

cg26359940

12

41,221,579

8.79E−07

CNTN1

TSS200; 5’UTR

cg11679914

7

99,662,323

9.38E−07

ZNF3 and ZSCAN21

3’UTR

cg13638229

10

131,697,080

9.90E−07

EBF3

Body

cg15055494

17

17,140,558

1.05E−06

FLCN

TSS200

cg10459387

3

180,319,718

1.11E−06

TTC14

TSS200

cg16379698

4

187,457,682

1.27E−06

MTNR1A

Body

cg03493516

16

29,742,019

1.30E−06

–

–

cg12593138

12

53,439,997

1.39E−06

TNS2 and LOC283335

TSS1500; Body

cg11701055

19

2,785,324

1.44E−06

THOP1

TSS200

cg02918253

19

19,323,996

1.50E−06

NCAN

5’UTR

cg16924102

4

20,044,588

1.65E−06

–

–

cg16063716

14

105,045,992

1.70E−06

C14orf180

TSS200

cg17089162

7

156,851,277

1.76E−06

–

–

cg12469150

18

60,992,501

1.82E−06

–

–

cg27446047

18

44,702,797

1.83E−06

IER3IP1

TSS200

cg13332944

17

16,769,594

2.20E−06

–

–

cg04927113

5

142,950,693

2.21E−06

–

–

cg03323503

17

80,965,251

2.22E−06

B3GNTL1

Body

cg13218425

10

4,868,364

2.30E−06

AKR1E2

TSS200

cg26878190

5

1,794,420

2.35E−06

–

–

cg22417797

12

101,801,627

2.37E−06

ARL1

TSS200

cg15682476

6

88,537,469

2.43E−06

LOC101928911

Body

cg03840924

17

47,645,509

2.43E−06

–

–

cg02352281

3

46,139,305

2.45E−06

–

–

cg22657044

20

48,551,982

2.55E−06

RNF114

TSS1500

cg21827912

4

86,763,803

2.63E−06

ARHGAP24

Body; 5’UTR

cg18377764

14

66,869,995

2.67E−06

–

–

cg20354777

3

140,814,133

2.70E−06

SPSB4

Body

cg09294095

11

131,630,464

2.81E−06

NTM

Body

cg00152975

19

17,981,922

2.82E−06

SLC5A5

TSS1500

cg09056281

1

84,164,484

2.83E−06

LOC101927587

Body

cg04631318

1

48,231,352

2.89E−06

TRABD2B

3’UTR

cg25094081

6

31,829,205

3.44E−06

NEU1

Body

cg16113298

11

31,832,729

3.66E−06

PAX6

5’UTR; 1stExon

cg14861221

3

57,743,016

3.74E−06

SLMAP

TSS200

cg01236268

22

49,552,838

3.86E−06

–

–

cg14185656

9

94,493,225

3.87E−06

ROR2

Body

cg00276256

10

1,330,230

3.88E−06

ADARB2

Body

cg07786675

1

27,189,985

3.95E−06

SFN

1stExon