Fig. 3

DMB-based binary clustering of tumor tissues and somatic mutation contributions in subtypes. A Consensus clustering of tumor tissue samples. B Relationships between subtypes and patient clinical features/molecular markers. C Distribution of the malignancy density ratio (MD ratio) across subtypes. D Somatic mutation landscape in the tested tumors (n = 44). E Detection ratios of driver gene mutations in the two subtypes. *: P < 0.05, **: P < 0.01