Fig. 2

Differentially methylated blocks (DMBs) in tumor tissues compared with peri-tumor and normal tissues. A Volcano plot of DMBs between tumor and peri-tumoral tissues. B Volcano plot of DMBs between tumor tissues and normal lung tissues. C Venn diagram depicting the distribution of DMBs across various tissues. D Gene Ontology enrichment of genes linked to tumor-specific hypermethylated DMBs. E KEGG pathway enrichment for genes linked to tumor-specific hypermethylated DMBs. F Expression of selected genes associated with hypermethylated DMBs in LUADs and normal tissues within the public datasets. *: P < 0.05