Fig. 1

Analysis of DNA methylation in LUAD patient tissues. A Distribution of DNA methylation blocks across the gene body. B Principal component analysis (PCA) of methylation profiles of various samples. C Analysis of the relationships between the top two principal components of the methylation profiles (Dim.1, Dim.2) and clinical characteristics. D Correlation between Dim.1 and patient age. *: P < 0.05, **: P < 0.01