Fig. 1

Forest plot with Cox proportional hazards from co-twin control analyses, SATSA (n = 491 individuals). Note: The values represent hazard ratios (HR) with a 95% Confidence Interval (CI) from stratified Cox proportional hazard models within MZ and DZ twin pairs. Swedish Adoption/Twin Study of Aging—SATSA. The confidence interval for MMP9 ranges from 3.03 to 93.7; however, it was not represented in the figure to enhance visualization. IGFBP4: Insulin-like growth factor-binding protein 4, LY9: Lymphocyte antigen 9, MMP9: Matrix metalloproteinase 9, NCAM1: Neural cell adhesion molecule 1, OSM: Oncostatin-M, PIGR: Polymeric immunoglobulin receptor, PREP: Prolyl endopeptidase, RARRES2: Retinoic acid receptor responder protein 2, S100A12: S100 calcium binding protein A12, SEMA3E: Semaphorin 3E, STC1: Stanniocalcin 1, TGFA: Transforming growth factor alpha, THBS2: Thrombospondin 2, WFIKKN2: WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2