Fig. 1

Metabolism-related diagram of novel histone modifications in HCC. This schematic highlights the interplay between various novel HPTMs and their corresponding metabolic pathways, focusing on the liver and its role in cancer progression. The diagram displays multiple types of acylation modifications, including ksuc, kcit, kbnb, kla, kcr, and khib, each modulated by specific “writers,” “erasers,” and “readers.” These metabolic intermediates, such as lactyl-CoA, succinyl-CoA, and crotonyl-CoA, originate from core metabolic processes and are critical for chromatin regulation