Table 2 Overview of the epigenetic age of neonates with various antenatal stresses
Group | Sample (n) | Age (years) | DNAm age (Mean ± SD) | DNAm age (ΔMean ± SD) | 95%CI | Cohen’s d | 95%CI | P value | Power (%) |
|---|---|---|---|---|---|---|---|---|---|
Human neonates | |||||||||
Full-term | 36 | 0 | 0.048 ± 0.025 | 0.070 ± 0.033 | [0.004, 0.136] | 0.501 | [0.030, 0.969] | 0.036 | 56.7 |
Preterm | 36 | 0 | − 0.022 ± 0.021 | ||||||
Preterm neonates with Antenatal steroid exposure | |||||||||
No | 12 | 0 | − 0.099 ± 0.028 | − 0.115 ± 0.042 | [− 0.199, − 0.030] | − 0.972 | [− 1.696, − 0.236] | 0.009 | 85.2 |
Yes | 24 | 0 | 0.015 ± 0.026 | ||||||
Preterm neonates with Antenatal magnesium sulfate exposure | |||||||||
No | 16 | 0 | − 0.012 ± 0.029 | 0.018 ± 0.044 | [− 0.070, 0.107] | 0.141 | [− 0.518, 0.798] | 0.633 | 7.1 |
Yes | 20 | 0 | − 0.031 ± 0.031 | ||||||
Preterm neonates born to mothers with Chorioamnionitis | |||||||||
No | 25 | 0 | − 0.027 ± 0.027 | − 0.013 ± 0.047 | [− 0.109, 0.082] | − 0.103 | [− 0.812, 0.607] | 0.693 | 6.1 |
Yes | 11 | 0 | − 0.013 ± 0.034 | ||||||
Preterm neonates born to mothers with Late-onset sepsis | |||||||||
No | 17 | 0 | − 0.061 ± 0.032 | − 0.074 ± 0.042 | [− 0.158, 0.011] | − 0.590 | [− 1.255, 0.083] | 0.096 | 42.0 |
Yes | 19 | 0 | 0.012 ± 0.027 | ||||||