Fig. 2

Effect of glucocorticoids exposure on the epigenetic age of human lung fibroblasts IMR90 cells and human fetal multipotent hippocampal progenitor HPC cells. A Comparison of DNAm age of IMR-90 cells pre-treated with vehicle, cortisol, relacorilant, or cortisol + relacorilant for 4 h. B Comparison of DNAm age of HPC cells treated with ethanol (Vehicle) or 1 μM of dexamethasone (Dex) during 3-day proliferation phase (Pro 3 days) or during both the 3-day proliferation and 7-day neuronal differentiation phases (Pro 3 days + Diff 7 days). The P value from Kruskal–Wallis tests is shown between the indicated comparisons