Fig. 1
From: HDAC inhibitors modulate Hippo pathway signaling in hormone positive breast cancer
RNA-seq of HR( +) breast cancer cells treated with romidepsin reveals pathway enrichment including cell cycle and Hippo pathways. A Venn diagram of differentially expressed genes (DEG) from RNA-seq data performed on MCF-7 or T47D cells, treated with either romidepsin 50 nM or DMSO for 24 h. B–D Gene ontology (GO) analysis (B), dot plot (C), and ridge plot (D) of DEGs from the RNA-seq data. E GSEA analysis for cell cycle pathway from the RNA-seq data. F Leading enriched pathways from DAVID analysis of the RNA-seq data. G, H Heat map of mRNA expression from the RNA-seq dataset of Hippo pathway signature genes [49] in T47D (G) and MCF-7 (H)