Fig. 3
From: Sex-specific role of epigenetic modification of a leptin upstream enhancer in adipose tissue
Relationship between sex-specific differences in leptin expression and enhancer DNA methylation levels in human visceral adipose tissue with body fat percentage. Heatmaps show Spearman correlation coefficients of enhancer DNA methylation, mRNA level, and serum levels of leptin with anthropometric phenotypes for female (A) and male (B) individuals with obesity. Positive correlations are shown in petrol and negative correlations in brown. Non-significant correlations (FDR < 0.1) are crossed out. C Scheme for causal mediation analysis exploring the mediation of sex-specific differences in body fat percentage via DNA methylation at the LEP upstream enhancer. Results of the mediation analysis are shown in Table 2. D Scheme for causal mediation analysis in female individuals exploring the mediation of the effect of DNA methylation at the LEP upstream enhancer on body fat percentage via leptin serum level. Results of the analysis are shown in Table 3