Table 1 Detailed descriptions of ‘decisions’
Decisions | Description |
|---|---|
Match | When the calibrated score reaches 0.9 or above, it aligns with the results derived from histopathology, clinical information, CNS tumor-targeted NGS panel results, and the initial pathological diagnosis |
Likely match | When the calibrated score falls below 0.9, histopathology, clinical information, CNS tumor-targeted NGS panel results, and the initial pathological diagnosis can be integrated to decide whether the methylation class is reliable. But keep in mind that the diagnosis can be changed |
Uncertain | The methylation classifier’s result remains uncertain, irrespective of the calibrated score |
No match | The methylation classifier’s result is incorrect |
Control (No match) | It is categorized as normal control, which can occur when DNA is extracted from regions with very low tumor purity or normal brains |