Fig. 2

Comparison of SNUH-MC-91 and DKFZ-MC Decisions: This figure compares the decision results of SNUH-MC-91 and DKFZ-MC across different calibrated score ranges. The decisions are categorized as follows: A All ranges: Distribution of all decisions regardless of calibrated score B Score ≥ 0.9: High-confidence decisions, C 0.9 > Score ≥ 0.5: Medium-confidence decisions, D Score < 0.5: Low-confidence decisions “Match” indicates cases where the methylation classifier result (with score ≥ 0.9) is consistent with histopathology, clinical information, and NGS findings. This comparison illustrates the performance and agreement of both classifiers with other diagnostic methods across various confidence levels, providing insights into their reliability in neuropathological diagnosis. (SNUH-MC: Seoul National University Hospital Methylation Classifier; DKFZ-MC: Deutsches Krebsforschungszentrum Methylation Classifier; NGS: Next Generation Sequencing)