Blood-based epigenome-wide association study and prediction of alcohol consumption

Clinical Epigenetics

Table 4 BayesR alcohol consumption (units per week, log(x + 1) transformed) EWAS associations with mean beta PIP > 0.8

Chr	CpG	Position	UCSC RefGene Name	Str	Mean Beta	SE	PIP
4	cg06690548	139,162,808	SLC7A11	−	−0.0876	0.0005	1	Normal week drinkers
7	cg26774981	104,907,846	SRPK2;SRPK2;SRPK2	−	0.1039	0.0005	1
9	cg05719472	80,914,400	PSAT1;PSAT1	−	0.0447	0.0003	0.999
6	cg18120259	43,894,639	LOC100132354	+	−0.0910	0.0008	0.981
1	cg24694018	145,457,621	POLR3GL	+	0.0572	0.0004	1	Everyone
4	cg06690548	139,162,808	SLC7A11	−	−0.0953	0.0004	1
7	cg26774981	104,907,846	SRPK2;SRPK2;SRPK2	−	0.0660	0.0005	1
2	cg06053623	68,778,314	–	−	−0.0464	0.0003	0.995
9	cg03741185	18,201,510	IL12RB1	+	−0.0504	0.0004	0.994
11	cg11376147	57,261,198	SLC43A1	−	−0.0798	0.0009	0.954

Chr = chromosome; Str = strand. Alcohol units defined as per NHS guidelines of 8 g/10 ml of pure ethanol

ISSN: 1868-7083