Fig. 5

TXNIP blocks cell cycle progression through p53. A The cell cycle-related proteins expression levels in TET2 knockdown ALCL cell lines and controls were determined by Western blot. B The p21 protein expression levels in TET2 knockdown ALCL cell lines and controls were determined by Western blot. C The cell cycle distribution of ALCL cell lines transfected with pcDNA3.1-TXNIP or pcDNA3.1-NC was determined by flow cytometry. D The cell proliferation ability of ALCL cell lines transfected with pcDNA3.1-TXNIP or pcDNA3.1-NC was determined by the CCK-8 assay. E The cell cycle-related proteins expression levels in TET2 knockdown ALCL cell lines transfected with pcDNA3.1-TXNIP or pcDNA3.1-NC were determined by Western blot. F The p21 protein expression levels in TET2 knockdown ALCL cell lines transfected with pcDNA3.1-TXNIP or pcDNA3.1-NC were determined by Western blot. G The cell cycle distribution of ALCL cell lines treated with PFTα or DMSO control after transfection with pcDNA3.1-TXNIP was determined by flow cytometry. H The cell proliferation ability of ALCL cell lines treated with PFTα or DMSO control after transfection with pcDNA3.1-TXNIP was determined by the CCK-8 assay. P, phosphorylation. All experiments were repeated three times independently (n = 3). Data were expressed as the mean ± SDs. * p < 0.05;  ** p < 0.01;  *** p < 0.001