Fig. 1
Decreased TET2 mediates low level of 5hmC in anaplastic large cell lymphoma patients. A Representative IHC staining of 5hmC in ALCL samples(n = 46) and reactive lymph nodes (n = 24). B IHC score analysis for 5hmC in in ALCL samples(n = 46) and reactive lymph nodes (n = 24). C Representative IHC staining of TET2 in ALCL samples (n = 46) and reactive lymph nodes (n = 24). D IHC score analysis for TET2 in ALCL samples (n = 46) and reactive lymph nodes (n = 24). E Representative IHC staining of 5hmC and TET2 with different levels in ALCL samples (n = 46). F Correlation of 5hmC expression and TET2 expression in ALCL samples (n = 46). G Kaplan–Meier survival curve of ALCL patients with different levels of 5hmC IHC score (n = 46). H Kaplan–Meier survival curve of ALCL patients with different levels of TET2 IHC score (n = 46). 5hmC, 5-Hydroxymethylcytosine, IHC, immunohistochemistry; ALCL, anaplastic large cell lymphoma. Data were expressed as the mean ± SDs. Representative images were captured at × 400 magnification. *p < 0.05; *p < 0.01;***p < 0.001