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Fig. 1 | Clinical Epigenetics

Fig. 1

From: How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health

Fig. 1

Epigenetic signatures in sperm. Sperm chromatin is tightly packaged by binding to protamines and histones (< 15% of the genome). DNA methylation occurs at CG-rich, histone-bound DNA regions and repetitive sequences. Environmental factors may influence DNA methylation, histone modification, as well as the expression of small non-coding RNA, such as tsRNA, microRNA, and PIWI-interacting RNA. The figure was adapted from Donkin and Barrès [44] and created with Biorender.com

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Clinical Epigenetics

ISSN: 1868-7083

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