Fig. 4
From: Hypoxia impairs decitabine-induced expression of HLA-DR in acute myeloid leukaemia cell lines
The effect of hypoxia on HMA-induced transcriptional changes in MOLM-13. RNA sequencing was performed on MOLM-13 cells. Heatmaps show differentially expressed genes (DEGs) following A AZA, or B DAC treatment within each oxygen tension. C, D Venn diagrams of genes up- or down-regulated by C AZA, or D DAC are accompanied by treeplots that present the top 15 gene pathways up-regulated in 21% O2 only. Enriched pathways were determined using FDR p-adjusted, p value cutoff = 0.05, q value cutoff = 0.2