Table 1 Ferroptosis-regulating microRNAs (miRNAs) in CVDs
Modification | Diseases | miRNA | Targets | Biological functions | References |
|---|---|---|---|---|---|
miRNA | MIRI | miR-135b-3p | GPX4 | miR-135b-3p promotes the myocardial I/R injury by downregulating GPX4 expression | [47] |
MIRI | miR-1224 | GPX4 | miR-1224 is highly expressed in H/R cardiomyocytes. Inhibition of miR-1224 affects GPX4 expression, reduces oxidative damage | [48] | |
MIRI | miR-144-3p | SLC7A11 | miR-144-3p negatively regulates SLC7A11 protein levels in H9C2 cells, enhances the sensitivity to ferroptosis | [49] | |
MIRI | miR-190a-5p | GLS2 | Overexpression of miR-190a-5p can inhibit GLS2, protect H9C2 cells from erastin and RSL3-induced ferroptosis | [50] | |
MIRI | miR-199a-5p | Akt/eNOS | miR-199a-5p promotesferroptosis during OGD/R by activating the Akt/eNOS signaling pathway | [51] | |
MIRI | miR-210–3p | TFR | miR-210-3p inhibiting TFR and promoting the proliferation of cardiomyocytes in H9C2 cells | [52] | |
MIRI | miR-432-5p | Nrf2 | miR432-5p inhibits ferroptosis by activating the Nrf2/SLC7A11 axis through degrading Keap1 | [53] | |
MIRI | miR-196c-3p | LOX、NOX4、P53 | miR-196c-3p can regulate the expression of LOX, NOX4, P53, inhibiting ferroptosis | [54] | |
AMI | miR-30d | ATG5 | miR-30d can bind to ATG5 to decreased in ferroptosis after MI | [55] | |
AMI | miR-15a-5p | GPX4 | Overexpression of miR-15a-5p strengthened ferroptosis by affects GPX4 expression | [56] | |
AMI | miR-214-3p | ME2 | miR-214-3p may contribute to cardiomyocyte ferroptosis via suppressing ME2, which could significantly lower NADPH level, leading to ROS burst and ferroptosis | [58] | |
AMI | miR-26b-5p | SLC7A11 | Plasma exosomes from patients with AMI can downregulate miR-26b-5p and upregulation of SLC7A11 inhibited hypoxia-induced ferroptosis | [59] | |
AMI | miR-23a-3p | DMT1 | HUCB-MSCs-exosomes may suppress DMT1 expression via miR-23a-3p, which reduces Fe2+ and MDA levels, inhibits ferroptosis | [60] | |
Cardiac fibrosis | miR-375-3p | GPX4 | miR-375-3p downregulate GPX4 and inhibiting the oxidative clearance function of superoxide dismutase, accelerating ferroptosis and cardiac fibrosis | [66] | |
Cardiac fibrosis | miR-351 | MLK3 | miR-351 negatively regulated the expression of MLK3, prevent myocardial fibrosis | [67] | |
AF | miR-23a-3p | SLC7A11 | In AF, inhibiting the secretion of exosomal miR-23a-3p by cardiac fibroblasts protects H9C2 myocardial cells from ferroptosis | [68] |