Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis

Table 1 All 19 methylated sites found between IgG4-SC and healthy controls from EWAS

Rank	IlmnID	Gene	Chr	Location	BetaHealthy Control	Beta IgG4-SC	Beta diff	P. Val	Adj. P. Val
1	cg22914762	MIR1973	4	Body	0.226	0.292	0.066	1.10E-23	9.50E-18
2	cg12949141	PCBD2	5	Body	0.262	0.421	0.158	2.99E-23	2.59E-17
3	cg13170468		11		0.301	0.377	0.076	5.47E-16	4.74E-10
4	cg00490885	MIR4485	11	TSS1500	0.178	0.234	0.056	9.32E-14	8.07E-08
5	cg03964851	MIR1974	5	TSS200	0.775	0.739	− 0.036	5.42E-13	4.69E-07
6	cg23505966	CEP97	3	1stExon	0.043	0.035	− 0.008	7.90E-12	6.84E-06
7	cg05812299	MTRNR2L5	10	TSS200	0.139	0.174	0.035	1.00E-11	8.68E-06
8	cg16581032		8		0.137	0.164	0.027	1.78E-11	1.54E-05
9	cg26094004	PYY	17	5'UTR	0.414	0.486	0.071	3.15E-10	0.0003
10	cg23492258	MTRNR2L5	10	TSS1500	0.366	0.443	0.077	1.18E-09	0.0010
11	cg14069320	IFNAR1	21	TSS1500	0.046	0.036	− 0.010	1.63E-09	0.0014
12	cg23558456		1		0.663	0.757	0.094	2.19E-09	0.0019
13	cg27143246	MYNN	3	TSS1500	0.286	0.216	− 0.069	4.39E-09	0.0038
14	cg15077985		18		0.769	0.839	0.070	1.19E-08	0.0103
15	cg24866706		3		0.796	0.861	0.065	1.26E-08	0.0109
16	cg08422863	HERC6	4	Body	0.183	0.130	− 0.053	1.79E-08	0.0155
17	cg02279883	TANC2	17	TSS1500	0.882	0.863	− 0.019	2.51E-08	0.0217
18	cg16267121	MTRNR2L3	20	TSS1500	0.159	0.184	0.025	3.04E-08	0.0263
19	cg18840034	WIBG	12	Body	0.680	0.753	0.073	5.40E-08	0.0468

ISSN: 1868-7083